Stem cell therapy in heart diseases–cell types, mechanisms and improvement strategies

P Müller, H Lemcke, R David - Cellular Physiology and Biochemistry, 2018 - karger.com
A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …

An overview of the molecular mechanisms associated with myocardial ischemic injury: state of the art and translational perspectives

L Schirone, M Forte, L D'Ambrosio, V Valenti… - Cells, 2022 - mdpi.com
Cardiovascular disease is the leading cause of death in western countries. Among
cardiovascular diseases, myocardial infarction represents a life-threatening condition …

[HTML][HTML] Exosomes from MiR-126-overexpressing adscs are therapeutic in relieving acute myocardial ischaemic injury

Q Luo, D Guo, G Liu, G Chen, M Hang… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Recent studies have indicated that exosomes play an important role in
adipose-derived stem cell (ADSC) transplant-mediated ischaemic heart disease therapy …

miR-93-5p-containing exosomes treatment attenuates acute myocardial infarction-induced myocardial damage

J Liu, M Jiang, S Deng, J Lu, H Huang, Y Zhang… - … Therapy Nucleic Acids, 2018 - cell.com
Adipose-derived stromal cells (ADSCs) have been considered as an attractive therapeutic
tool. Accumulating evidence indicates that the healing effects of ADSCs are mainly related to …

Stem cell-derived cell sheet transplantation for heart tissue repair in myocardial infarction

R Guo, M Morimatsu, T Feng, F Lan, D Chang… - Stem Cell Research & …, 2020 - Springer
Stem cell-derived sheet engineering has been developed as the next-generation treatment
for myocardial infarction (MI) and offers attractive advantages in comparison with direct stem …

[HTML][HTML] Cell sheet formation enhances the therapeutic effects of human umbilical cord mesenchymal stem cells on myocardial infarction as a bioactive material

R Guo, F Wan, M Morimatsu, Q Xu, T Feng, H Yang… - Bioactive materials, 2021 - Elsevier
Stem cell-based therapy has been used to treat ischaemic heart diseases for two decades.
However, optimal cell types and transplantation methods remain unclear. This study …

Application of mesenchymal stem cell sheet to treatment of ischemic heart disease

D Chang, T Fan, S Gao, Y **, M Zhang… - Stem Cell Research & …, 2021 - Springer
In recent years, mesenchymal stem cells (MSCs) have been used to improve cardiac
function and attenuate adverse ventricular remodeling of the ischemic myocardium through …

Tissue engineering using a combined cell sheet technology and scaffolding approach

IM Zurina, VS Presniakova, DV Butnaru, AA Svistunov… - Acta Biomaterialia, 2020 - Elsevier
Cell sheet technology has remained quite popular among tissue engineering techniques
over the last several years. Meanwhile, there is an apparent trend in modern scientific …

Recent advances in cell sheet engineering: from fabrication to clinical translation

P Thummarati, W Laiwattanapaisal, R Nitta, M Fukuda… - Bioengineering, 2023 - mdpi.com
Cell sheet engineering, a scaffold-free tissue fabrication technique, has proven to be an
important breakthrough technology in regenerative medicine. Over the past two decades …

Adipose tissue and the vascularization of biomaterials: stem cells, microvascular fragments and nanofat—a review

P Kamat, FS Frueh, M McLuckie, N Sanchez-Macedo… - Cytotherapy, 2020 - Elsevier
Tissue defects in the human body after trauma and injury require precise reconstruction to
regain function. Hence, there is a great demand for clinically translatable approaches with …