Advancing biological investigations using portable sensors for detection of sensitive samples

AK Wani, N Akhtar, V Katoch, S Shukla, US Kadam… - Heliyon, 2023 - cell.com
Portable biosensors have emerged as powerful diagnostic tools for analyzing sensitive
biological samples. These biosensors offer sensitive detection capabilities by utilizing …

Development of lycopene-based whole-cell biosensors for the visual detection of trace explosives and heavy metals

M Li, S Lv, R Yang, X Chu, X Wang, Z Wang… - Analytica Chimica …, 2023 - Elsevier
Residual explosives in conflicting zones have caused irreversible damage to human safety
and the environment. Whole-cell biosensors can to detect remnants of buried explosives …

Design and optimization of E. coli artificial genetic circuits for detection of explosive composition 2, 4-dinitrotoluene

Y Zhang, ZP Zou, SY Chen, WP Wei, Y Zhou… - Biosensors and …, 2022 - Elsevier
The detection of mine-based explosives poses a serious threat to the lives of deminers, and
carcinogenic residues may cause severe environmental pollution. Whole-cell biosensors …

Controlling the sensitivity and selectivity for the detection of nitro-based explosives by modulating the electronic substituents on the ligand of AIPE-active …

A Agarwal, RP Bhatta, V Kachwal, IR Laskar - Dalton Transactions, 2023 - pubs.rsc.org
Nitroaromatic compounds are extremely explosive materials that pose a national security
risk and raise environmental concerns. The design and development of sensitive and …

Structural basis of transcription factor YhaJ for DNT detection

M Kim, R Kang, TJ Jeon, SE Ryu - Iscience, 2023 - cell.com
Detection of landmines without harming personnel is a global issue. The bacterial
transcription factor YhaJ selectively detects metabolites of explosives, and it can be used as …

High-affinity promotor binding of YhaJ mediates a low signal leakage for effective DNT detection

M Kim, R Kang, HM Park, EB Cho, HR Lee… - Frontiers in …, 2025 - frontiersin.org
The YhaJ transcription factor responds to dinitrophenol (DNT) and its metabolic products.
The YhaJ-involving cells have been exploited for whole-cell biosensors of soil-buried …

Introduction of quorum sensing elements into bacterial bioreporter circuits enhances explosives' detection capabilities

E Shpigel, S Nathansohn, A Glozman… - Engineering in Life …, 2022 - Wiley Online Library
A possible solution for the standoff detection of buried landmines is based on the use of
microbial bioreporters, genetically engineered to emit a remotely detectable optical signal in …

[HTML][HTML] Performance upgrade of a microbial explosives' sensor strain by screening a high throughput saturation library of a transcriptional regulator

L David, E Shpigel, I Levin, S Moshe… - Computational and …, 2023 - Elsevier
We present a methodology for a high-throughput screening (HTS) of transcription factor
libraries, based on bacterial cells and GFP fluorescence. The method is demonstrated on …

Design of bacterial DNT sensors based on computational models

S Bahiri Elitzur, E Shpigel, I Katzir, U Alon, S Belkin… - bioRxiv, 2024 - biorxiv.org
Detecting explosive compounds such as 2, 4, 6-trinitrotoluene (TNT) and its volatile
byproduct 2, 4-dinitrotoluene (DNT) is paramount for public health and environmental safety …