Molecular mechanisms of human hypertension

RP Lifton, AG Gharavi, DS Geller - Cell, 2001 - cell.com
Hypertension, or elevated arterial blood pressure, is a been operationally defined as the
blood pressure level substantial public health problem, affecting 25% of the above which …

Candidate-gene approaches for studying complex genetic traits: practical considerations

HK Tabor, NJ Risch, RM Myers - Nature Reviews Genetics, 2002 - nature.com
Association studies with candidate genes have been widely used for the study of complex
diseases. However, this approach has been criticized because of non-replication of results …

Pathogenesis of hypertension

S Oparil, MA Zaman, DA Calhoun - Annals of internal medicine, 2003 - acpjournals.org
Increased recognition of specific causes of hypertension may lead to therapies that address
specific pathophysiologic mechanisms and cause fewer adverse effects. Research to …

Exploring the biological contributions to human health: does sex matter?

ML Pardue, TM Wizemann - 2001 - books.google.com
It's obvious why only men develop prostate cancer and why only women get ovarian cancer.
But it is not obvious why women are more likely to recover language ability after a stroke …

Sex-specific genetic architecture of human disease

C Ober, DA Loisel, Y Gilad - Nature Reviews Genetics, 2008 - nature.com
Sexual dimorphism in anatomical, physiological and behavioural traits are characteristics of
many vertebrate species. In humans, sexual dimorphism is also observed in the prevalence …

The role of exercise training in the treatment of hypertension: an update

JM Hagberg, JJ Park, MD Brown - Sports medicine, 2000 - Springer
Hypertension is a very prevalent cardiovascular (CV) disease risk factor in developed
countries. All current treatment guidelines emphasise the role of nonpharmacological …

Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure

MD Tobin, NA Sheehan, KJ Scurrah… - Statistics in …, 2005 - Wiley Online Library
A population‐based study of a quantitative trait may be seriously compromised when the
trait is subject to the effects of a treatment. For example, in a typical study of quantitative …

Hypertension and the risk of dementia

C Sierra - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Hypertension, particularly midlife high blood pressure, has been related to a higher risk of
cognitive decline and dementia, including Alzheimer disease. However, these associations …

Evidence for a gene influencing blood pressure on chromosome 17: genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the …

D Levy, AL DeStefano, MG Larson, CJ O'Donnell… - …, 2000 - Am Heart Assoc
Hypertension is a leading cause of morbidity and mortality. Efforts to identify hypertension
genes have focused on 3 approaches: mendelian disorders, candidate genes, and genome …

Renin angiotensin system and gender differences in the cardiovascular system

M Fischer, A Baessler, H Schunkert - Cardiovascular research, 2002 - academic.oup.com
In the effort to explain gender-related differences of the cardiovascular system, the renin–
angiotensin system experienced intensive exploration. Indeed, the development of …