Parkinson's disease: Mechanisms, translational models and management strategies

C Raza, R Anjum - Life sciences, 2019 - Elsevier
Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …

European academy of neurology/Movement Disorder Society‐European section guideline on the treatment of Parkinson's disease: I. Invasive therapies

G Deuschl, A Antonini, J Costa… - European Journal of …, 2022 - Wiley Online Library
Abstract Background and Purpose This update of the treatment guidelines was
commissioned by the European Academy of Neurology and the European section of the …

Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson's disease: a blinded randomized feasibility trial

CR Oehrn, S Cernera, LH Hammer, M Shcherbakova… - Nature Medicine, 2024 - nature.com
Deep brain stimulation (DBS) is a widely used therapy for Parkinson's disease (PD) but
lacks dynamic responsiveness to changing clinical and neural states. Feedback control …

Predicting optimal deep brain stimulation parameters for Parkinson's disease using functional MRI and machine learning

A Boutet, R Madhavan, GJB Elias, SE Joel… - Nature …, 2021 - nature.com
Commonly used for Parkinson's disease (PD), deep brain stimulation (DBS) produces
marked clinical benefits when optimized. However, assessing the large number of possible …

International Parkinson and movement disorder society evidence‐based medicine review: update on treatments for the motor symptoms of Parkinson's disease

SH Fox, R Katzenschlager, SY Lim, B Barton… - Movement …, 2018 - Wiley Online Library
Objective: The objective of this review was to update evidence‐based medicine
recommendations for treating motor symptoms of Parkinson's disease (PD). Background …

Long-term outcomes of deep brain stimulation in Parkinson disease

P Limousin, T Foltynie - Nature Reviews Neurology, 2019 - nature.com
The efficacy of deep brain stimulation (DBS) for Parkinson disease (PD) is well established
for up to 1 or 2 years, but long-term outcome data are still limited. In this Review, we critically …

[HTML][HTML] Parkinson's disease and its management: part 1: disease entity, risk factors, pathophysiology, clinical presentation, and diagnosis

G DeMaagd, A Philip - Pharmacy and therapeutics, 2015 - ncbi.nlm.nih.gov
Parkinson’s Disease and Its Management - PMC Back to Top Skip to main content NIH NLM
Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Search …

Toward defining deep brain stimulation targets in MNI space: a subcortical atlas based on multimodal MRI, histology and structural connectivity

S Ewert, P Plettig, N Li, MM Chakravarty, DL Collins… - Neuroimage, 2018 - Elsevier
Three-dimensional atlases of subcortical brain structures are valuable tools to reference
anatomy in neuroscience and neurology. For instance, they can be used to study the …

A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder

N Li, JC Baldermann, A Kibleur, S Treu… - Nature …, 2020 - nature.com
Multiple surgical targets for treating obsessive-compulsive disorder with deep brain
stimulation (DBS) have been proposed. However, different targets may modulate the same …

Direct and indirect pathways of basal ganglia: a critical reappraisal

P Calabresi, B Picconi, A Tozzi, V Ghiglieri… - Nature …, 2014 - nature.com
The basal ganglia are subcortical nuclei controlling voluntary actions and have been
implicated in Parkinson's disease (PD). The prevailing model of basal ganglia function …