Molecular dynamics simulations in drug discovery and pharmaceutical development
Molecular dynamics (MD) simulations have become increasingly useful in the modern drug
development process. In this review, we give a broad overview of the current application …
development process. In this review, we give a broad overview of the current application …
The role of noradrenaline in cognition and cognitive disorders
Many aspects of cognition and behaviour are regulated by noradrenergic projections to the
forebrain originating from the locus coeruleus, acting through alpha and beta …
forebrain originating from the locus coeruleus, acting through alpha and beta …
Near‐Infrared Aggregation‐Induced Emission Luminogens for In Vivo Theranostics of Alzheimer's Disease
T Zhang, X Chen, C Yuan, X Pang… - Angewandte Chemie …, 2023 - Wiley Online Library
Optimized theranostic strategies for Alzheimer's disease (AD) remain almost absent from
bench to clinic. Current probes and drugs attempting to prevent β‐amyloid (Aβ) fibrosis …
bench to clinic. Current probes and drugs attempting to prevent β‐amyloid (Aβ) fibrosis …
High-frequency terahertz waves disrupt Alzheimer's β-amyloid fibril formation
W Peng, Z Zhu, J Lou, K Chen, Y Wu, C Chang - eLight, 2023 - Springer
The accumulation and deposition of amyloid can cause a variety of neurodegenerative
diseases, including Alzheimer's and Parkinson's disease. The degradation or clearance of …
diseases, including Alzheimer's and Parkinson's disease. The degradation or clearance of …
[HTML][HTML] Recent developments in molecular modeling tools and applications related to pharmaceutical and biomedical research
In modern pharmaceutical and biomedical research, molecular modeling represents a
useful tool to explore processes and their mechanistic bases at the molecular level …
useful tool to explore processes and their mechanistic bases at the molecular level …
Spontaneous formation of β-sheet nano-barrels during the early aggregation of Alzheimer's amyloid beta
Soluble low-molecular-weight oligomers formed during the early aggregation of amyloid
peptides have been hypothesized as a major toxic species of amyloidogenesis. Herein, we …
peptides have been hypothesized as a major toxic species of amyloidogenesis. Herein, we …
Molecular mechanisms of resveratrol and EGCG in the inhibition of Aβ 42 aggregation and disruption of Aβ 42 protofibril: Similarities and differences
The aggregation of amyloid-β protein (Aβ) into fibrillary deposits is implicated in Alzheimer's
disease (AD), and inhibiting Aβ aggregation and clearing Aβ fibrils are considered as …
disease (AD), and inhibiting Aβ aggregation and clearing Aβ fibrils are considered as …
[HTML][HTML] Noradrenergic neuromodulation in ageing and disease
F Krohn, E Lancini, M Ludwig, M Leiman… - Neuroscience & …, 2023 - Elsevier
The locus coeruleus (LC) is a small brainstem structure located in the lower pons and is the
main source of noradrenaline (NA) in the brain. Via its phasic and tonic firing, it modulates …
main source of noradrenaline (NA) in the brain. Via its phasic and tonic firing, it modulates …
A comprehensive insight into the mechanisms of dopamine in disrupting Aβ protofibrils and inhibiting Aβ aggregation
Fibrillary aggregates of amyloid-β (Aβ) are the pathological hallmark of Alzheimer's disease
(AD). Clearing Aβ deposition or inhibiting Aβ aggregation is a promising approach to treat …
(AD). Clearing Aβ deposition or inhibiting Aβ aggregation is a promising approach to treat …
Recent advances in the design and applications of amyloid-β peptide aggregation inhibitors for Alzheimer's disease therapy
Alzheimer's disease (AD) is an irreversible neurological disorder that progresses gradually
and can cause severe cognitive and behavioral impairments. This disease is currently …
and can cause severe cognitive and behavioral impairments. This disease is currently …