[HTML][HTML] Mastering complexity: towards bottom-up construction of multifunctional eukaryotic synthetic cells

K Göpfrich, I Platzman, JP Spatz - Trends in biotechnology, 2018‏ - cell.com
With the ultimate aim to construct a living cell, bottom-up synthetic biology strives to
reconstitute cellular phenomena in vitro–disentangled from the complex environment of a …

Synthetic cells revisited: Artificial cell construction using polymeric building blocks

V Maffeis, L Heuberger, A Nikoletić… - Advanced …, 2024‏ - Wiley Online Library
The exponential growth of research on artificial cells and organelles underscores their
potential as tools to advance the understanding of fundamental biological processes. The …

Kinetically Controlled and Nonequilibrium Assembly of Block Copolymers in Solution

SDP Fielden - Journal of the American Chemical Society, 2024‏ - ACS Publications
Covalent polymers are versatile macromolecules that have found widespread use in society.
Contemporary methods of polymerization have made it possible to construct sequence …

[HTML][HTML] Mitochondrial cristae architecture and functions: lessons from minimal model systems

F Joubert, N Puff - Membranes, 2021‏ - mdpi.com
Mitochondria are known as the powerhouse of eukaryotic cells. Energy production occurs in
specific dynamic membrane invaginations in the inner mitochondrial membrane called …

Membrane curvature induces cardiolipin sorting

E Beltrán-Heredia, FC Tsai… - Communications …, 2019‏ - nature.com
Cardiolipin is a cone-shaped lipid predominantly localized in curved membrane sites of
bacteria and in the mitochondrial cristae. This specific localization has been argued to be …

Non-equilibrium self-assembly for living matter-like properties

A Singh, P Parvin, B Saha, D Das - Nature Reviews Chemistry, 2024‏ - nature.com
The soft and wet machines of life emerged as the spatially enclosed ensemble of
biomolecules with replicating capabilities integrated with metabolic reaction cycles that …

[HTML][HTML] Modeling membranes in situ

CM Brown, SJ Marrink - Current Opinion in Structural Biology, 2024‏ - Elsevier
Molecular dynamics simulations of cellular membranes have come a long way—from simple
model lipid bilayers to multicomponent systems capturing the crowded and complex nature …

Function investigations and applications of membrane proteins on Artificial lipid membranes

T Tosaka, K Kamiya - International Journal of Molecular Sciences, 2023‏ - mdpi.com
Membrane proteins play an important role in key cellular functions, such as signal
transduction, apoptosis, and metabolism. Therefore, structural and functional studies of …

Constructing artificial respiratory chain in polymer compartments: Insights into the interplay between bo3 oxidase and the membrane

N Marušič, L Otrin, Z Zhao, RB Lira, FL Kyrilis… - Proceedings of the …, 2020‏ - pnas.org
Cytochrome bo 3 ubiquinol oxidase is a transmembrane protein, which oxidizes ubiquinone
and reduces oxygen, while pum** protons. Apart from its combination with F1Fo-ATPase …

Molecular shape solution for mesoscopic remodeling of cellular membranes

PV Bashkirov, PI Kuzmin, J Vera Lillo… - Annual review of …, 2022‏ - annualreviews.org
Cellular membranes self-assemble from and interact with various molecular species. Each
molecule locally shapes the lipid bilayer, the soft elastic core of cellular membranes. The …