[HTML][HTML] Cell heterogeneity uncovered by single-cell RNA sequencing offers potential therapeutic targets for ischemic stroke
M Qiu, J Zong, Q He, Y Liu, Y Wan, M Li, Y Zhou… - Aging and …, 2022 - ncbi.nlm.nih.gov
Ischemic stroke is a detrimental neurological disease characterized by an irreversible infarct
core surrounded by an ischemic penumbra, a salvageable region of brain tissue. Unique …
core surrounded by an ischemic penumbra, a salvageable region of brain tissue. Unique …
[HTML][HTML] Vascular adhesion protein-1 (VAP-1) in vascular inflammatory diseases
M Danielli, RC Thomas, LM Quinn, BK Tan - Vasa, 2022 - econtent.hogrefe.com
Vascular adhesion protein-1 (VAP-1) also known as amino oxidase copper containing 3
(AOC3) is a pro-inflammatory and versatile molecule with adhesive and enzymatic …
(AOC3) is a pro-inflammatory and versatile molecule with adhesive and enzymatic …
[HTML][HTML] Immp2l knockdown in male mice increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico …
Cortico-striatal neurocircuits mediate goal-directed and habitual actions which are
necessary for adaptive behaviour. It has recently been proposed that some of the core …
necessary for adaptive behaviour. It has recently been proposed that some of the core …
[HTML][HTML] Engineered macrophage-biomimetic versatile nanoantidotes for inflammation-targeted therapy against Alzheimer's disease by neurotoxin neutralization and …
M Cheng, C Ye, C Tian, D Zhao, H Li, Z Sun, Y Miao… - Bioactive Materials, 2023 - Elsevier
Immune recognition of excessive neurotoxins by microglia is a trigger for the onset of
neuroinflammation in the brain, leading to neurodegeneration in Alzheimer's disease (AD) …
neuroinflammation in the brain, leading to neurodegeneration in Alzheimer's disease (AD) …
Cognitive effects of thalamostriatal degeneration are ameliorated by normalizing striatal cholinergic activity
The loss of neurons in parafascicular thalamus (Pf) and their inputs to dorsomedial striatum
(DMS) in Lewy body disease (LBD) and Parkinson's disease dementia (PDD) have been …
(DMS) in Lewy body disease (LBD) and Parkinson's disease dementia (PDD) have been …
Combining monoamine oxidase B and semicarbazide-sensitive amine oxidase enzyme inhibition to address inflammatory disease
JS Foot, A Buson, M Deodhar, AD Findlay… - Bioorganic & Medicinal …, 2022 - Elsevier
The discovery of a dual MAO-B/SSAO inhibitor PXS-5131 is reported. The compound offers
a compact and rigid three-dimensional structure with superior selectivity over MAO-A …
a compact and rigid three-dimensional structure with superior selectivity over MAO-A …
Animal models of action control and cognitive dysfunction in Parkinson's disease
BW Balleine - Progress in Brain Research, 2022 - Elsevier
Parkinson's disease (PD) has historically been considered a motor disorder induced by a
loss of dopaminergic neurons in the substantia nigra pars compacta. More recently, it has …
loss of dopaminergic neurons in the substantia nigra pars compacta. More recently, it has …
[HTML][HTML] Habitual behaviour associated with exposure to high-calorie diet is prevented by an orexin-receptor-1 antagonist
Habitual actions, which are associated with addictive behaviours, contribute to the loss of
control of food seeking seen following exposure to calorie-dense foods in rats. Antagonism …
control of food seeking seen following exposure to calorie-dense foods in rats. Antagonism …
Immp2l knockdown increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a mouse …
Cortico-striatal neurocircuits mediate goal-directed and habitual actions which are
necessary for adaptive behaviour. It has recently been proposed that some of the core …
necessary for adaptive behaviour. It has recently been proposed that some of the core …
[HTML][HTML] Discovery of genes prominent in ADHD and SUDs: A meta-analysis and review
Y Gao, C Sang, G Shen, Y Xu - Theoretical and Natural Science, 2024 - ewadirect.com
Abstract Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neuropsychiatric
condition characterized by symptoms of inattention, hyperactivity, and impulsivity, with a high …
condition characterized by symptoms of inattention, hyperactivity, and impulsivity, with a high …