Head and neck squamous cell carcinoma (HNSCC) is the sixth most common non-skin
cancer with a tobacco consumption and infection with high-risk human papillomavirus (HPV) …

Radiotherapy is one of the most common treatments for oral cancer. However, in the clinic,
recurrence and metastasis of oral cancer occur after radiotherapy, and the underlying …

The majority of cancer cells have a functional mitochondrial electron transport chain (ETC).
Mitochondrial complex I is the primary entry point into the ETC, where oxidative …

Metformin, a US Food and Drug Administration-approved “star” drug used for diabetes
mellitus type 2, has become a topic of increasing interest to researchers due to its anti …

Metformin (MET), 1, 1-dimethylbiguanide hydrochloride, is a biguanide drug used as the first-
line medication in the treatment of type 2 diabetes. The recent years have brought many …

This study aimed to expand our understanding of metformin (Met) in inhibiting hepatocellular
carcinoma (HCC) progression and to investigate its underlying mechanism. Met was …

Cancer stem cells (CSCs) are considered to be responsible for tumor recurrence and
metastasis. Therefore, clarification of the mechanisms involved in CSC stemness …

Metformin is the most used drug for type 2 diabetes (T2DM). Its antitumor activity has been
described by clinical studies showing reduced risk of cancer development in T2DM patients …

Breast cancer stem cells (BCSCs) are a major cause of therapy resistance and tumour
progression. Currently, their regulation is not entirely understood. Previous work from our …

Background Metformin is a commonly used antidiabetic medication which has demonstrated
promise as an anticancer agent alone and in combination with conventional treatment …