Understanding the genetic alterations, disrupted signaling pathways, and hijacked
mechanisms in oncogene-transformed hematologic cells is critical for the development of …

The Hedgehog (HH) signaling network is one of the main regulators of invertebrate and
vertebrate embryonic development. Along with other networks, such as NOTCH and WNT …

Epithelial barrier tissues such as the skin and airway form an essential interface between the
mammalian host and its external environment. These physical barriers are crucial to prevent …

Isolated left ventricular noncompaction (LVNC) results from excessive trabeculation and
impaired myocardial compaction during heart development. The extracellular matrix (ECM) …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive childhood leukemia that is
caused by the accumulation of multiple genomic lesions resulting in transcriptional …

Simple Summary Inner Mongolia Albas white cashmere goat is a unique biological resource
in Northwest China, and the cashmere produced by goat is sold well at home and abroad …

ABSTRACT Gli3 is a Hedgehog (Hh)-responsive transcription factor that can function as a
transcriptional repressor or activator. We show that Gli3 activity in mouse thymic epithelial …

Before birth, B cells develop in the fetal liver (FL). In this study, we show that Gli3 activity in
the FL stroma is required for B cell development. In the Gli3-deficient FL, B cell development …

Kif7 is a ciliary kinesin motor protein that regulates mammalian Hedgehog pathway
activation through influencing structure of the primary cilium. Here we show that Kif7 is …

Abstract The Foxa1 and Foxa2 transcription factors are essential for mouse development.
Here we show that they are expressed in thymic epithelial cells (TEC) where they regulate …