Immune checkpoint therapy—current perspectives and future directions
Immune checkpoint therapy (ICT) has dramatically altered clinical outcomes for cancer
patients and conferred durable clinical benefits, including cure in a subset of patients …
patients and conferred durable clinical benefits, including cure in a subset of patients …
Macrophages as tools and targets in cancer therapy
A Mantovani, P Allavena, F Marchesi… - Nature Reviews Drug …, 2022 - nature.com
Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …
[HTML][HTML] Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment
The use of probiotics by cancer patients is increasing, including among those undergoing
immune checkpoint inhibitor (ICI) treatment. Here, we elucidate a critical microbial-host …
immune checkpoint inhibitor (ICI) treatment. Here, we elucidate a critical microbial-host …
Bacteria in cancer initiation, promotion and progression
Cancer cells originate from a series of acquired genetic mutations that can drive their
uncontrolled cell proliferation and immune evasion. Environmental factors, including the …
uncontrolled cell proliferation and immune evasion. Environmental factors, including the …
[HTML][HTML] Microbiota in health and diseases
The role of microbiota in health and diseases is being highlighted by numerous studies
since its discovery. Depending on the localized regions, microbiota can be classified into …
since its discovery. Depending on the localized regions, microbiota can be classified into …
Gut microbiota in colorectal cancer development and therapy
Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …
is its intimate association with the gut microbiota, which forms an essential part of the tumour …
[HTML][HTML] Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer
A Fu, B Yao, T Dong, Y Chen, J Yao, Y Liu, H Li, H Bai… - Cell, 2022 - cell.com
Tumor-resident intracellular microbiota is an emerging tumor component that has been
documented for a variety of cancer types with unclear biological functions. Here, we …
documented for a variety of cancer types with unclear biological functions. Here, we …
Targeting the gut and tumor microbiota in cancer
Microorganisms within the gut and other niches may contribute to carcinogenesis, as well as
sha** cancer immunosurveillance and response to immunotherapy. Our understanding of …
sha** cancer immunosurveillance and response to immunotherapy. Our understanding of …
Resistance mechanisms to anti-PD cancer immunotherapy
The transformative success of antibodies targeting the PD-1 (programmed death 1)/B7-H1
(B7 homolog 1) pathway (anti-PD therapy) has revolutionized cancer treatment. However …
(B7 homolog 1) pathway (anti-PD therapy) has revolutionized cancer treatment. However …
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer
Aside from PD-L1 expression, biomarkers of response to immune checkpoint inhibitors (ICIs)
in non-small-cell lung cancer (NSCLC) are needed. In a previous retrospective analysis, we …
in non-small-cell lung cancer (NSCLC) are needed. In a previous retrospective analysis, we …