The intestinal barrier protects the host against gut microbes, food antigens, and toxins
present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic …

The interplay between the commensal microbiota and the mammalian immune system
development and function includes multifold interactions in homeostasis and disease. The …

In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing
damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi …

The gut microbiome plays an important role in human health and influences the
development of chronic diseases ranging from metabolic disease to gastrointestinal …

Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

The role and molecular mechanisms of intermittent fasting (IF) in non-alcoholic
steatohepatitis (NASH) and its transition to hepatocellular carcinoma (HCC) are unknown …

Secondary bile acids (SBAs) are derived from primary bile acids (PBAs) in a process reliant
on biosynthetic capabilities possessed by few microbes. To evaluate the role of BAs in …

T cells are integral in mediating adaptive immunity to infection, autoimmunity, and cancer.
Upon immune challenge, T cells exit from a quiescent state, followed by clonal expansion …

The development of intestinal organoids from single adult intestinal stem cells in vitro
recapitulates the regenerative capacity of the intestinal epithelium,. Here we unravel the …

Intermittent and periodic fasting (IF and PF, respectively) are emerging as safe strategies to
affect longevity and healthspan by acting on cellular aging and disease risk factors, while …