The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Calcium (Ca2+) ions act as a second messenger, regulating several cell functions.
Mitochondria are critical organelles for the regulation of intracellular Ca2+. Mitochondrial …

Background: The mitochondrial calcium uniporter (mtCU) is an≈ 700-kD multisubunit
channel residing in the inner mitochondrial membrane required for mitochondrial Ca2+ …

Abstract Mitochondrial Ca 2+(mitCa 2+) uptake controls both intraorganellar and cytosolic
functions. Within the organelle,[Ca 2+] increases regulate the activity of tricarboxylic acid …

Background Globally, the onset and progression of multiple human diseases are associated
with mitochondrial dysfunction and dysregulation of Ca 2+ uptake dynamics mediated by the …

Ca2+ ions serve as pleiotropic second messengers in the cell, regulating several cellular
processes. Mitochondria play a fundamental role in Ca2+ homeostasis since mitochondrial …

Mitochondria house evolutionarily conserved pathways of carbon and nitrogen metabolism
that drive cellular energy production. Mitochondrial bioenergetics is regulated by calcium …

The notion of mitochondria being involved in the decoding and sha** of intracellular Ca2+
signals has been circulating since the end of the 19th century. Despite that, the molecular …

Coiled coils are a widespread and well understood protein fold. Their short and simple
repeats underpin considerable structural and functional diversity. The vast majority of coiled …

Calcium entering mitochondria potently stimulates ATP synthesis. Increases in calcium
preserve energy synthesis in cardiomyopathies caused by mitochondrial dysfunction, and …