Inflammation has been linked to multiple degenerative and acute diseases as well as the
aging process. Moreover, mitochondrial alterations play a central role in these processes …

Inflammasomes play essential roles in immune protection against microbial infections.
However, excessive inflammation is implicated in various human diseases, including …

The inflammasome complex is important for host defense against intracellular bacterial
infections. Mycobacterium tuberculosis (Mtb) is a facultative intracellular bacterium which is …

Fusobacterium nucleatum is an invasive anaerobic bacterium that is associated with
periodontal disease. Previous studies have focused on virulence factors produced by F …

The intracellular production of reactive oxygen species (ROS), composed of oxygen-
reduced molecules, is important not only because of their lethal effects on microorganisms …

Inflammation is associated with the release of soluble mediators that drive cellular activation
and migration of inflammatory leukocytes to the site of injury, together with endothelial …

The inflammasome is a multi-protein complex that induces maturation of inflammatory
cytokines interleukin (IL)-1β and IL-18 through activation of caspase-1. Several nucleotide …

Trypanosoma cruzi (T. cruzi) is an intracellular protozoan parasite and the etiological agent
of Chagas disease, a chronic infectious illness that affects millions of people worldwide …

The production of IL-1β during the infection with Mycobacterium tuberculosis (Mtb) is
important for successful host immune defense. In macrophages and dendritic cells the host …

Although it has been known for decades that patients with type 2 diabetes mellitus (DM) are
more susceptible to severe tuberculosis (TB) infection, the underlying immunological …