The metabolomic window into hepatobiliary disease

D Beyoğlu, JR Idle - Journal of hepatology, 2013 - Elsevier
The emergent discipline of metabolomics has attracted considerable research effort in
hepatology. Here we review the metabolomic data for non-alcoholic fatty liver disease …

NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology

M Coen, E Holmes, JC Lindon… - Chemical research in …, 2008 - ACS Publications
We have reviewed the main contributions to the development of NMR-based metabonomic
and metabolic profiling approaches for toxicological assessment, biomarker discovery, and …

Persistent organic pollutants modify gut microbiota–host metabolic homeostasis in mice through aryl hydrocarbon receptor activation

L Zhang, RG Nichols, J Correll, IA Murray… - Environmental …, 2015 - ehp.niehs.nih.gov
Background Alteration of the gut microbiota through diet and environmental contaminants
may disturb physiological homeostasis, leading to various diseases including obesity and …

High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues

O Beckonert, M Coen, HC Keun, Y Wang… - Nature protocols, 2010 - nature.com
Metabolic profiling, metabolomic and metabonomic studies require robust study protocols for
any large-scale comparisons and evaluations. Detailed methods for solution-state NMR …

Urinary metabolic phenoty** differentiates children with autism from their unaffected siblings and age-matched controls

IKS Yap, M Angley, KA Veselkov… - Journal of proteome …, 2010 - ACS Publications
Autism is an early onset developmental disorder with a severe life-long impact on behavior
and social functioning that has associated metabolic abnormalities. The urinary metabolic …

Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in rats: a rapid in vivo screening method for nanotoxicity

R Lei, C Wu, B Yang, H Ma, C Shi, Q Wang… - Toxicology and applied …, 2008 - Elsevier
Despite an increasing application of copper nanoparticles, there is a serious lack of
information concerning their impact on human health and the environment. In this study, the …

Dynamic Metabonomic Responses of Tobacco (Nicotiana tabacum) Plants to Salt Stress

J Zhang, Y Zhang, Y Du, S Chen… - Journal of proteome …, 2011 - ACS Publications
Metabolic responses are important for plant adaptation to osmotic stresses. To understand
the dosage and duration dependence of salinity effects on plant metabolisms, we analyzed …

Metabonomic Studies of Human Hepatocellular Carcinoma Using High-Resolution Magic-Angle Spinning 1H NMR Spectroscopy in Conjunction with Multivariate …

Y Yang, C Li, X Nie, X Feng, W Chen… - Journal of proteome …, 2007 - ACS Publications
High-resolution magic-angle spinning (MAS) 1H nuclear magnetic resonance spectroscopy
has been employed to characterize the metabolite composition (ie, metabonome) of the …

Systems responses of rats to aflatoxin B1 exposure revealed with metabonomic changes in multiple biological matrices

L Zhang, Y Ye, Y An, Y Tian, Y Wang… - Journal of proteome …, 2011 - ACS Publications
Exposure to aflatoxins causes liver fibrosis and hepatocellular carcinoma posing a
significant health risk for human populations and livestock. To understand the mammalian …

Combined NMR and LC-MS Analysis Reveals the Metabonomic Changes in Salvia miltiorrhiza Bunge Induced by Water Depletion

H Dai, C **ao, H Liu, H Tang - Journal of proteome research, 2010 - ACS Publications
Plant metabonomic analysis is essential for understanding plant systems responses to
osmotic stresses. To understand the comprehensive metabolic responses of Salvia …