The recent years saw the advent of promising preclinical strategies that combat the
devastating effects of a spinal cord injury (SCI) that are progressing towards clinical trials …

▪ Abstract Nerve regeneration is a complex biological phenomenon. In the peripheral
nervous system, nerves can regenerate on their own if injuries are small. Larger injuries …

Spinal cord injury (SCI) can lead to paraplegia or quadriplegia. Although there are no fully
restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have …

This review considers the 2 sources of neurotrophic factors in the peripheral nervous system
(PNS), the neurons and the nonneuronal cells in the denervated distal nerve stumps, and …

Tissue engineering of nerve grafts requires synergistic combination of scaffolds and
techniques to promote and direct neurite outgrowth across the lesion for effective nerve …

The spinal cord is part of the central nervous system (CNS) and serves to connect the brain
to the peripheral nervous system and peripheral tissues. The cell types that primarily …

Functional restoration after spinal cord injury (SCI) is one of the most challenging tasks in
neurological clinical practice. With a view to exploring effective neurorestorative methods in …

Elevated intraocular pressure (IOP) in glaucoma causes loss of retinal ganglion cells
(RGCs) and damage to the optic nerve. Although IOP is controlled pharmacologically, no …

The precise wiring of the adult mammalian CNS originates during a period of stunning
growth, guidance and plasticity that occurs during and shortly after development. When …

Stem cell therapy is a potential treatment for spinal cord injury (SCI), and a variety of different
stem cell types have been evaluated in animal models and humans with SCI. No consensus …