Breast cancer is a global cause for concern owing to its high incidence around the world.
The alarming increase in breast cancer cases emphasizes the management of disease at …

Mutations in the BRCA1 and/or BRCA2 genes (BRCAm) increase the risk of develo**
breast cancer (BC) and are found in~ 5% of unselected patients with the disease. BC …

PURPOSE To develop recommendations for germline mutation testing for patients with
breast cancer. METHODS An ASCO–Society of Surgical Oncology (SSO) panel convened to …

Historically, professional society guidelines have recommended limited genetic testing for
hereditary cancer syndromes (HCS) to patients with cancer thought to be at highest risk for …

PURPOSE To determine the contribution of germline pathogenic variants (PVs) in hereditary
cancer testing panel genes to invasive lobular carcinoma (ILC) of the breast. MATERIALS …

Purpose: Lynch syndrome is defined by germline pathogenic mutations involving DNA
mismatch repair (MMR) genes and linked with the development of MMR-deficient colon and …

Purpose: To determine the relationship between germline pathogenic variants (PV) in
cancer predisposition genes and the risk of ductal carcinoma in situ (DCIS). Experimental …

Brazil is the largest country in South America and the most genetically heterogeneous. The
aim of the present study was to determine the prevalence of germline pathogenic variants …

For women with breast cancer, the value of identifying a high-penetrance mutation in a
breast cancer gene is well-established. It provides the opportunity for contralateral …

Current methods of next generation sequencing may simultaneously detect multiple
germline breast cancer susceptibility variants. However, it is a challenge to maximize the …