We have produced gene expression profiles of all 302 neurons of the C. elegans nervous
system that match the single-cell resolution of its anatomy and wiring diagram. Our results …

The studies of cell fate and lineage specification are fundamental to our understanding of
the development of multicellular organisms. Caenorhabditis elegans has been one of the …

Most heritable traits, including disease susceptibility, are affected by interactions between
multiple genes. However, we understand little about how genes interact because very few …

The C. elegans hermaphrodite vulva is an established model system to study mechanisms
of cell fate specification and tissue morphogenesis. The adult vulva is a tubular shaped …

Summary The let-7 microRNA (miRNA) regulates stemness in animals ranging from worms
to humans. However, the cause of the dramatic vulval rupturing phenotype of let-7 mutant C …

The orientation of asymmetric cell division contributes to the organization of cells within a
tissue or organ. For example, mirror-image symmetry of the C. elegans vulva is achieved by …

An understanding of cell-invasive behavior has been limited by the lack of in vivo models
where this activity can be clearly visualized and manipulated. We show that a single cell in …

Wnt proteins are intercellular signals that regulate various aspects of animal development. In
Caenorhabditis elegans, mutations in lin-17, a Frizzled-class Wnt receptor, and in lin-18 …

Background During the fourth larval (L4) stage, vulval cells of C. elegans undergo extensive
morphogenesis accompanied by changes in gene expression. This phase of vulval …

Notch signaling is critical for cell fate decisions during development. Caenorhabditis
elegans and vertebrate Notch ligands are more diverse than classical Drosophila Notch …