Considerations for building and using integrated single-cell atlases

K Hrovatin, L Sikkema, VA Shitov, G Heimberg… - Nature …, 2024 - nature.com
The rapid adoption of single-cell technologies has created an opportunity to build single-cell
'atlases' integrating diverse datasets across many laboratories. Such atlases can serve as a …

An in-depth comparison of linear and non-linear joint embedding methods for bulk and single-cell multi-omics

S Makrodimitris, B Pronk, T Abdelaal… - Briefings in …, 2024 - academic.oup.com
Multi-omic analyses are necessary to understand the complex biological processes taking
place at the tissue and cell level, but also to make reliable predictions about, for example …

Novel multi-omics deconfounding variational autoencoders can obtain meaningful disease subty**

Z Li, S Katz, E Saccenti, DW Fardo… - Briefings in …, 2024 - academic.oup.com
Unsupervised learning, particularly clustering, plays a pivotal role in disease subty** and
patient stratification, especially with the abundance of large-scale multi-omics data. Deep …

Variational graph autoencoder for reconstructed transcriptomic data associated with NLRP3 mediated pyroptosis in periodontitis

PK Yadalam, PM Natarajan, CM Ardila - Scientific Reports, 2025 - nature.com
The NLRP3 inflammasome, regulated by TLR4, plays a pivotal role in periodontitis by
mediating inflammatory cytokine release and bone loss induced by Porphyromonas …

Early multi-cancer detection through deep learning: An anomaly detection approach using Variational Autoencoder

IT Sado, LF Fitime, GF Pelap, C Tinku… - Journal of Biomedical …, 2024 - Elsevier
Cancer is a disease that causes many deaths worldwide. The treatment of cancer is first and
foremost a matter of detection, a treatment that is most effective when the disease is detected …

Detecting subtle transcriptomic perturbations induced by lncRNAs knock-down in single-cell CRISPRi screening using a new sparse supervised autoencoder neural …

M Truchi, C Lacoux, C Gille, J Fassy… - Frontiers in …, 2024 - frontiersin.org
Single-cell CRISPR-based transcriptome screens are potent genetic tools for concomitantly
assessing the expression profiles of cells targeted by a set of guides RNA (gRNA), and …

How Do Big Data and Generative AI Dawn on Computational Biology?

S Jauhari - Unraveling New Frontiers and Advances in …, 2024 - Springer
The theme of Generative AI has opened a nasty Pandora's Box in the recent epoch, where
there is an open debate on the benefits and caveats that it brings to the table. From current …

Multimodální variační autoenkodér pro generování akcí na základě instrukcí

Š Gabriela - 2024 - dspace.cvut.cz
Multimodální variační autoenkodéry (VAE) jsou generativní modely umožňující propojení
jednotlivých datových vstupů do společné latentní reprezentace, nebo generování jedné …