The wide implementation of next-generation sequencing (NGS) technologies has
revolutionized the field of medical genetics. However, the short read lengths of currently …

In the past several years, single-molecule sequencing platforms, such as those by Pacific
Biosciences and Oxford Nanopore Technologies, have become available to researchers …

Calcium signalling has long been implicated in bipolar disorder, especially by reports of
altered intracellular calcium ion concentrations ([Ca2+]). However, the evidence has not …

Eukaryotic genes often generate a variety of RNA isoforms that can lead to functionally
distinct protein variants. The synthesis and stability of RNA isoforms is poorly characterized …

We reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-
gated calcium channels are risk genes for several disorders. Second, use of CCBs is …

The molecular pathogenesis of hematological diseases is often driven by genetic and
epigenetic alterations. Next-generation sequencing has considerably increased our …

Risk-taking behaviour is an important component of several psychiatric disorders, including
attention-deficit hyperactivity disorder, schizophrenia and bipolar disorder. Previously, two …

The olive fruit fly, Bactrocera oleae, is the most important pest for the olive fruit but lacks
adequate transcriptomic characterization that could aid in molecular control approaches. We …

The major anti-hypertensive (AHT) drug classes have been associated with differential risks
of psychiatric disorders. However, existing data are limited largely to depression, and …

Alternative splicing (AS) is a crucial posttranscriptional mechanism of gene expression
which promotes transcriptome and proteome diversity. At the molecular level, splicing and …