The genetic basis of moyamoya disease
Moyamoya disease (MMD) is a rare cerebrovascular disease characterized by progressive
spontaneous bilateral occlusion of the intracranial internal cerebral arteries (ICA) and their …
spontaneous bilateral occlusion of the intracranial internal cerebral arteries (ICA) and their …
RNF213 and GUCY1A3 in moyamoya disease: key regulators of metabolism, inflammation, and vascular stability
Y Mineharu, S Miyamoto - Frontiers in Neurology, 2021 - frontiersin.org
Moyamoya disease is an idiopathic chronically progressive cerebrovascular disease, which
causes both ischemic and hemorrhagic stroke. Genetic studies identified RNF213/Mysterin …
causes both ischemic and hemorrhagic stroke. Genetic studies identified RNF213/Mysterin …
Moyamoya Disease Susceptibility Gene RNF213 Regulates Endothelial Barrier Function
Background: Variants in the ring finger protein 213 (RNF213) gene are known to be
associated with increased predisposition to cerebrovascular diseases development …
associated with increased predisposition to cerebrovascular diseases development …
The application of convolutional neural network to stem cell biology
Induced pluripotent stem cells (iPSC) are one the most prominent innovations of medical
research in the last few decades. iPSCs can be easily generated from human somatic cells …
research in the last few decades. iPSCs can be easily generated from human somatic cells …
Differentiation, evaluation, and application of human induced pluripotent stem cell–derived endothelial cells
The emergence of induced pluripotent stem cell (iPSC) technology paves the way to
generate large numbers of patient-specific endothelial cells (ECs) that can be potentially …
generate large numbers of patient-specific endothelial cells (ECs) that can be potentially …
Novel multifaceted roles for RNF213 protein
G Pollaci, G Gorla, A Potenza, T Carrozzini… - International Journal of …, 2022 - mdpi.com
Ring Finger Protein 213 (RNF213), also known as Mysterin, is the major susceptibility factor
for Moyamoya Arteriopathy (MA), a progressive cerebrovascular disorder that often leads to …
for Moyamoya Arteriopathy (MA), a progressive cerebrovascular disorder that often leads to …
Induced pluripotent stem cell-based drug screening by use of artificial intelligence
Induced pluripotent stem cells (iPSCs) are terminally differentiated somatic cells that
differentiate into various cell types. iPSCs are expected to be used for disease modeling and …
differentiate into various cell types. iPSCs are expected to be used for disease modeling and …
Endothelial cells harbouring the JAK2V617F mutation display pro-adherent and pro-thrombotic features
A Guadall, E Lesteven, G Letort, SA Toor… - Thrombosis and …, 2018 - thieme-connect.com
Thromboembolic events are the main cause of mortality in BCR-ABL1-negative
myeloproliferative neoplasms (MPNs) but their underlying mechanisms are largely …
myeloproliferative neoplasms (MPNs) but their underlying mechanisms are largely …
Hypoxia as a driving force of pluripotent stem cell reprogramming and differentiation to endothelial cells
P Podkalicka, J Stępniewski, O Mucha… - Biomolecules, 2020 - mdpi.com
Inadequate supply of oxygen (O2) is a hallmark of many diseases, in particular those related
to the cardiovascular system. On the other hand, tissue hypoxia is an important factor …
to the cardiovascular system. On the other hand, tissue hypoxia is an important factor …
Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease
Background The genetic architecture of coronary artery disease has not been fully
elucidated, especially in Asian countries. Moyamoya disease is a progressive …
elucidated, especially in Asian countries. Moyamoya disease is a progressive …