Star polymers: Advances in biomedical applications

W Wu, W Wang, J Li - Progress in Polymer Science, 2015 - Elsevier
Over the past decade, star polymers have been widely used in biomedical applications such
as drug delivery, gene delivery, tissue engineering, diagnosis, medical devices, and …

Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications

Y Liang, KL Kiick - Acta biomaterialia, 2014 - Elsevier
Heparin plays an important role in many biological processes via its interaction with various
proteins, and hydrogels and nanoparticles comprising heparin exhibit attractive properties …

Cross-linking and degradation of step-growth hydrogels formed by thiol–ene photoclick chemistry

H Shih, CC Lin - Biomacromolecules, 2012 - ACS Publications
Thiol–ene photoclick hydrogels have been used for a variety of tissue engineering and
controlled release applications. In this step-growth photopolymerization scheme, four-arm …

Hydrogels that listen to cells: a review of cell-responsive strategies in biomaterial design for tissue regeneration

HW Ooi, S Hafeez, CA Van Blitterswijk, L Moroni… - Materials …, 2017 - pubs.rsc.org
The past decade has seen a decided move from static and passive biomaterials to
biodegradable, dynamic, and stimuli responsive materials in the laboratory and the clinic …

Glycosaminoglycan‐based biohybrid hydrogels: a sweet and smart choice for multifunctional biomaterials

U Freudenberg, Y Liang, KL Kiick… - Advanced …, 2016 - Wiley Online Library
Glycosaminoglycans (GAGs) govern important functional characteristics of the extracellular
matrix (ECM) in living tissues. Incorporation of GAGs into biomaterials opens up new routes …

3D culture method for Alzheimer's disease modeling reveals interleukin-4 rescues Aβ42-induced loss of human neural stem cell plasticity

C Papadimitriou, H Celikkaya, MI Cosacak… - Developmental cell, 2018 - cell.com
Neural stem cells (NSCs) constitute an endogenous reservoir for neurons that could
potentially be harnessed for regenerative therapies in disease contexts such as …

Glycosaminoglycan-based hydrogels to modulate heterocellular communication in in vitro angiogenesis models

K Chwalek, MV Tsurkan, U Freudenberg, C Werner - Scientific reports, 2014 - nature.com
Angiogenesis, the outgrowth of blood vessels, is crucial in development, disease and
regeneration. Studying angiogenesis in vitro remains challenging because the capillary …

Incorporation of heparin into biomaterials

SE Sakiyama-Elbert - Acta biomaterialia, 2014 - Elsevier
This review provides an overview of the incorporation of heparin into biomaterials with a
focus on drug delivery and the use of heparin-based biomaterials for self-assembly of …

Instructing human macrophage polarization by stiffness and glycosaminoglycan functionalization in 3D collagen networks

M Friedemann, L Kalbitzer, S Franz… - Advanced …, 2017 - Wiley Online Library
Dynamic alterations of composition and mechanics of the extracellular matrix are suggested
to modulate cellular behavior including plasticity of macrophages (MPhs) during wound …

Bio-responsive polymer hydrogels homeostatically regulate blood coagulation

MF Maitz, U Freudenberg, MV Tsurkan… - Nature …, 2013 - nature.com
Bio-responsive polymer architectures can empower medical therapies by engaging
molecular feedback-response mechanisms resembling the homeostatic adaptation of living …