Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Zinc signals and immunity
M Maywald, I Wessels, L Rink - International journal of molecular sciences, 2017 - mdpi.com
Zinc homeostasis is crucial for an adequate function of the immune system. Zinc deficiency
as well as zinc excess result in severe disturbances in immune cell numbers and activities …
as well as zinc excess result in severe disturbances in immune cell numbers and activities …
Crystal structure of a heterotetrameric NMDA receptor ion channel
E Karakas, H Furukawa - Science, 2014 - science.org
N-Methyl-d-aspartate (NMDA) receptors belong to the family of ionotropic glutamate
receptors, which mediate most excitatory synaptic transmission in mammalian brains …
receptors, which mediate most excitatory synaptic transmission in mammalian brains …
NMDA receptor structures reveal subunit arrangement and pore architecture
Abstract N-methyl-d-aspartate (NMDA) receptors are Hebbian-like coincidence detectors,
requiring binding of glycine and glutamate in combination with the relief of voltage …
requiring binding of glycine and glutamate in combination with the relief of voltage …
Molecular basis of NMDA receptor functional diversity
P Paoletti - European Journal of Neuroscience, 2011 - Wiley Online Library
NMDA receptors (NMDARs) form glutamate‐gated ion channels widely expressed in the
central nervous system and highly permeable to calcium ions. NMDARs have always …
central nervous system and highly permeable to calcium ions. NMDARs have always …
Activation of NMDA receptors and the mechanism of inhibition by ifenprodil
The physiology of N-methyl-d-aspartate (NMDA) receptors is fundamental to brain
development and function. NMDA receptors are ionotropic glutamate receptors that function …
development and function. NMDA receptors are ionotropic glutamate receptors that function …
Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors
E Karakas, N Simorowski, H Furukawa - Nature, 2011 - nature.com
Since it was discovered that the anti-hypertensive agent ifenprodil has neuroprotective
activity through its effects on NMDA (N-methyl-D-aspartate) receptors, a determined effort …
activity through its effects on NMDA (N-methyl-D-aspartate) receptors, a determined effort …
Anti-NMDA receptor encephalitis antibody binding is dependent on amino acid identity of a small region within the GluN1 amino terminal domain
Anti-NMDA receptor (NMDAR) encephalitis is a newly identified autoimmune disorder that
targets NMDARs, causing severe neurological symptoms including hallucinations …
targets NMDARs, causing severe neurological symptoms including hallucinations …
NMDA receptors in the central nervous system
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major
component of excitatory neurotransmission in the central nervous system (CNS). They are …
component of excitatory neurotransmission in the central nervous system (CNS). They are …
Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation
INTRODUCTION Chemical neurotransmission is fundamental to communication between
neurons and to the alternation of the “strength” of neuron-to-neuron connections in an …
neurons and to the alternation of the “strength” of neuron-to-neuron connections in an …