Neuromesodermal progenitors and the making of the spinal cord
Neuromesodermal progenitors (NMps) contribute to both the elongating spinal cord and the
adjacent paraxial mesoderm. It has been assumed that these cells arise as a result of …
adjacent paraxial mesoderm. It has been assumed that these cells arise as a result of …
TGF-β signaling in cell fate control and cancer
Y Yu, XH Feng - Current opinion in cell biology, 2019 - Elsevier
Members of the transforming growth factor-β (TGF-β) family regulate cell fate decisions
during early embryonic development and tissue homeostasis in the adult. Deregulation of …
during early embryonic development and tissue homeostasis in the adult. Deregulation of …
A method to recapitulate early embryonic spatial patterning in human embryonic stem cells
Embryos allocate cells to the three germ layers in a spatially ordered sequence. Human
embryonic stem cells (hESCs) can generate the three germ layers in culture; however …
embryonic stem cells (hESCs) can generate the three germ layers in culture; however …
Self-organizing neuruloids model developmental aspects of Huntington's disease in the ectodermal compartment
Harnessing the potential of human embryonic stem cells to mimic normal and aberrant
development with standardized models is a pressing challenge. Here we use micropattern …
development with standardized models is a pressing challenge. Here we use micropattern …
Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6
Human induced pluripotent stem cells (hiPSCs) have potential for personalized and
regenerative medicine. While most of the methods using these cells have focused on …
regenerative medicine. While most of the methods using these cells have focused on …
Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors
AA Sproul, S Jacob, D Pre, SH Kim, MW Nestor… - PloS one, 2014 - journals.plos.org
Presenilin 1 (PSEN1) encodes the catalytic subunit of γ-secretase, and PSEN1 mutations
are the most common cause of early onset familial Alzheimer's disease (FAD). In order to …
are the most common cause of early onset familial Alzheimer's disease (FAD). In order to …
Posttranscriptional control of the stem cell and neurogenic programs by the nonsense-mediated RNA decay pathway
The mechanisms dictating whether a cell proliferates or differentiates have undergone
intense scrutiny, but they remain poorly understood. Here, we report that UPF1, a central …
intense scrutiny, but they remain poorly understood. Here, we report that UPF1, a central …
Potential energy landscapes identify the information-theoretic nature of the epigenome
Epigenetics is the study of biochemical modifications carrying information independent of
DNA sequence, which are heritable through cell division. In 1940, Waddington coined the …
DNA sequence, which are heritable through cell division. In 1940, Waddington coined the …
Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
H Kempf, R Olmer, A Haase, A Franke… - Nature …, 2016 - nature.com
In vitro differentiation of human pluripotent stem cells (hPSCs) recapitulates early aspects of
human embryogenesis, but the underlying processes are poorly understood and controlled …
human embryogenesis, but the underlying processes are poorly understood and controlled …
Is this a brain which I see before me? Modeling human neural development with pluripotent stem cells
The human brain is arguably the most complex structure among living organisms. However,
the specific mechanisms leading to this complexity remain incompletely understood …
the specific mechanisms leading to this complexity remain incompletely understood …