Challenges in glioblastoma immunotherapy: mechanisms of resistance and therapeutic approaches to overcome them

KJ Habashy, R Mansour, C Moussalem… - British journal of …, 2022 - nature.com
Glioblastoma is the most common and aggressive primary malignant brain tumour. The
prognosis of patients with glioblastoma is poor, and their overall survival averages at 1 year …

Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression

AT Yeo, S Rawal, B Delcuze, A Christofides… - Nature …, 2022 - nature.com
Glioblastoma (GBM) is an incurable primary malignant brain cancer hallmarked with a
substantial protumorigenic immune component. Knowledge of the GBM immune …

Chimeric antigen receptor T-cell therapy in glioblastoma: current and future

L Li, X Zhu, Y Qian, X Yuan, Y Ding, D Hu… - Frontiers in …, 2020 - frontiersin.org
Glioblastoma (GBM) is a highly aggressive glioma with an extremely poor prognosis after
conventional treatment. Recent advances in immunotherapy offer hope for these patients …

Investigating the Interactions of Glioma Stem Cells in the Perivascular Niche at Single‐Cell Resolution using a Microfluidic Tumor Microenvironment Model

EA Adjei‐Sowah, SA O'Connor, J Veldhuizen… - Advanced …, 2022 - Wiley Online Library
The perivascular niche (PVN) is a glioblastoma tumor microenvironment (TME) that serves
as a safe haven for glioma stem cells (GSCs), and acts as a reservoir that inevitably leads to …

A crowdsourced consensus on supratotal resection versus gross total resection for anatomically distinct primary glioblastoma

AM Khalafallah, M Rakovec, C Bettegowda… - …, 2021 - journals.lww.com
BACKGROUND Gross total resection (GTR) of contrast-enhancing tumor is associated with
increased survival in primary glioblastoma. Recently, there has been increasing interest in …

Innovations in intraoperative therapies in neurosurgical oncology: a narrative review

B Rodriguez, D Rivera, JY Zhang, C Brown… - Journal of Neuro …, 2024 - Springer
Purpose High-grade gliomas (HGG) represent the most aggressive primary brain tumors in
adults, characterized by high recurrence rates due to incomplete resection. This review …

Photodynamic and sonodynamic therapy synergy: mechanistic insights and cellular responses against glioblastoma multiforme

S Sharma, GB Gone, P Roychowdhury… - Journal of Drug …, 2024 - Taylor & Francis
Glioblastoma multiforme (GBM), the most aggressive form of brain cancer, poses substantial
challenges to effective treatment due to its complex and infiltrative nature, making it difficult …

Artificial intelligence-based locoregional markers of brain peritumoral microenvironment

Z Riahi Samani, D Parker, H Akbari, RL Wolf, S Brem… - Scientific Reports, 2023 - nature.com
In malignant primary brain tumors, cancer cells infiltrate into the peritumoral brain structures
which results in inevitable recurrence. Quantitative assessment of infiltrative heterogeneity in …

Intraarterial delivery of virotherapy for glioblastoma

VM Srinivasan, FF Lang, P Kan - Neurosurgical focus, 2021 - thejns.org
Oncolytic viruses (OVs) have been used in the treatment of cancer, in a focused manner,
since the 1990s. These OVs have become popular in the treatment of several cancers but …

Application of single cell sequencing technology in ovarian cancer research

Q Yuan, N Lv, Q Chen, S Shen, Y Wang… - Functional & Integrative …, 2024 - Springer
Ovarian cancer is a malignant tumor of ovary. It has the characteristics of difficult early
diagnosis, poor late curative effect and high recurrence rate. It is the biggest disease that …