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Challenges in glioblastoma immunotherapy: mechanisms of resistance and therapeutic approaches to overcome them
KJ Habashy, R Mansour, C Moussalem… - British journal of …, 2022 - nature.com
Glioblastoma is the most common and aggressive primary malignant brain tumour. The
prognosis of patients with glioblastoma is poor, and their overall survival averages at 1 year …
prognosis of patients with glioblastoma is poor, and their overall survival averages at 1 year …
Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression
Glioblastoma (GBM) is an incurable primary malignant brain cancer hallmarked with a
substantial protumorigenic immune component. Knowledge of the GBM immune …
substantial protumorigenic immune component. Knowledge of the GBM immune …
Chimeric antigen receptor T-cell therapy in glioblastoma: current and future
L Li, X Zhu, Y Qian, X Yuan, Y Ding, D Hu… - Frontiers in …, 2020 - frontiersin.org
Glioblastoma (GBM) is a highly aggressive glioma with an extremely poor prognosis after
conventional treatment. Recent advances in immunotherapy offer hope for these patients …
conventional treatment. Recent advances in immunotherapy offer hope for these patients …
Investigating the Interactions of Glioma Stem Cells in the Perivascular Niche at Single‐Cell Resolution using a Microfluidic Tumor Microenvironment Model
EA Adjei‐Sowah, SA O'Connor, J Veldhuizen… - Advanced …, 2022 - Wiley Online Library
The perivascular niche (PVN) is a glioblastoma tumor microenvironment (TME) that serves
as a safe haven for glioma stem cells (GSCs), and acts as a reservoir that inevitably leads to …
as a safe haven for glioma stem cells (GSCs), and acts as a reservoir that inevitably leads to …
A crowdsourced consensus on supratotal resection versus gross total resection for anatomically distinct primary glioblastoma
AM Khalafallah, M Rakovec, C Bettegowda… - …, 2021 - journals.lww.com
BACKGROUND Gross total resection (GTR) of contrast-enhancing tumor is associated with
increased survival in primary glioblastoma. Recently, there has been increasing interest in …
increased survival in primary glioblastoma. Recently, there has been increasing interest in …
Innovations in intraoperative therapies in neurosurgical oncology: a narrative review
B Rodriguez, D Rivera, JY Zhang, C Brown… - Journal of Neuro …, 2024 - Springer
Purpose High-grade gliomas (HGG) represent the most aggressive primary brain tumors in
adults, characterized by high recurrence rates due to incomplete resection. This review …
adults, characterized by high recurrence rates due to incomplete resection. This review …
Photodynamic and sonodynamic therapy synergy: mechanistic insights and cellular responses against glioblastoma multiforme
S Sharma, GB Gone, P Roychowdhury… - Journal of Drug …, 2024 - Taylor & Francis
Glioblastoma multiforme (GBM), the most aggressive form of brain cancer, poses substantial
challenges to effective treatment due to its complex and infiltrative nature, making it difficult …
challenges to effective treatment due to its complex and infiltrative nature, making it difficult …
Artificial intelligence-based locoregional markers of brain peritumoral microenvironment
In malignant primary brain tumors, cancer cells infiltrate into the peritumoral brain structures
which results in inevitable recurrence. Quantitative assessment of infiltrative heterogeneity in …
which results in inevitable recurrence. Quantitative assessment of infiltrative heterogeneity in …
Intraarterial delivery of virotherapy for glioblastoma
VM Srinivasan, FF Lang, P Kan - Neurosurgical focus, 2021 - thejns.org
Oncolytic viruses (OVs) have been used in the treatment of cancer, in a focused manner,
since the 1990s. These OVs have become popular in the treatment of several cancers but …
since the 1990s. These OVs have become popular in the treatment of several cancers but …
Application of single cell sequencing technology in ovarian cancer research
Q Yuan, N Lv, Q Chen, S Shen, Y Wang… - Functional & Integrative …, 2024 - Springer
Ovarian cancer is a malignant tumor of ovary. It has the characteristics of difficult early
diagnosis, poor late curative effect and high recurrence rate. It is the biggest disease that …
diagnosis, poor late curative effect and high recurrence rate. It is the biggest disease that …