Polymer folding through active processes recreates features of genome organization

A Goychuk, D Kannan, AK Chakraborty… - Proceedings of the …, 2023 - pnas.org
From proteins to chromosomes, polymers fold into specific conformations that control their
biological function. Polymer folding has long been studied with equilibrium thermodynamics …

Chromosome dynamics during interphase: a biophysical perspective

MMC Tortora, H Salari, D Jost - Current opinion in genetics & development, 2020 - Elsevier
The dynamic nature of chromosome organization plays a central role in the regulation of
many crucial processes, such as DNA transcription and replication. However, the molecular …

Dynamic ParB–DNA interactions initiate and maintain a partition condensate for bacterial chromosome segregation

M Tišma, R Janissen, H Antar… - Nucleic acids …, 2023 - academic.oup.com
In most bacteria, chromosome segregation is driven by the ParAB S system where the
CTPase protein ParB loads at the parS site to trigger the formation of a large partition …

Activity-induced collapse and arrest of active polymer rings

E Locatelli, V Bianco, P Malgaretti - Physical review letters, 2021 - APS
We investigate, using numerical simulations, the conformations of isolated active ring
polymers. We find that their behavior depends crucially on their size: Short rings (N≲ 100) …

Temporally correlated active forces drive segregation and enhanced dynamics in chromosome polymers

S Brahmachari, T Markovich, FC MacKintosh… - PRX Life, 2024 - APS
Understanding the mechanisms governing the structure and dynamics of flexible polymers
like chromosomes, especially the signatures of motor-driven active processes, is of great …

Tangentially driven active polar linear polymers—An analytical study

CA Philipps, G Gompper, RG Winkler - The Journal of Chemical …, 2022 - pubs.aip.org
The conformational and dynamical properties of isolated flexible active polar linear polymers
(APLPs) are studied analytically. The APLPs are modeled as Gaussian bead-spring linear …

Conformation and dynamics of partially active linear polymers

M Vatin, S Kundu, E Locatelli - Soft Matter, 2024 - pubs.rsc.org
We perform numerical simulations of isolated, partially active polymers, driven out-of-
equilibrium by a fraction of their monomers. We show that, if the active beads are all …

Migration and separation of polymers in nonuniform active baths

PL Muzzeddu, A Gambassi, JU Sommer, A Sharma - Physical Review Letters, 2024 - APS
Polymerlike structures are ubiquitous in nature and synthetic materials. Their configurational
and migration properties are often affected by crowded environments leading to nonthermal …

Self-organized states from solutions of active ring polymers in bulk and under confinement

JP Miranda, E Locatelli, C Valeriani - Journal of Chemical Theory …, 2023 - ACS Publications
In the present work, we study, by means of numerical simulations, the structural and
dynamical behavior of a suspension of active ring polymers in bulk and under lateral …

Conformation and dynamics of a self-avoiding active flexible polymer

SK Anand, SP Singh - Physical Review E, 2020 - APS
We investigate conformations and dynamics of a polymer considering its monomers to be
active Brownian particles. This active polymer shows very intriguing physical behavior which …