As an ancient infectious disease, tuberculosis (TB) is still the leading cause of death from a
single infectious agent worldwide. Latent TB infection (LTBI) has been recognized as the …

Protein therapeutics hold a prominent and rapidly expanding place among medicinal
products. Purified blood products, recombinant cytokines, growth factors, enzyme …

One of the great surprises of the biologics revolution has been the discovery that
recombinant human proteins, including monoclonals of human origin, can cause immune …

Vaccine informatics is an emerging research area that focuses on development and
applications of bioinformatics methods that can be used to facilitate every aspect of the …

There are more cases of tuberculosis in the world today than at any other time in history. The
global epidemic has generated intense interest into the immunological mechanisms that …

Summary Bacille Calmette–Guérin (BCG), developed a century ago, is the only licensed
tuberculosis (TB) vaccine in use to date. The protective efficacy of BCG against TB varies …

The aim of this study is to identify immune correlates of protection against tuberculosis
induced by the current vaccine, Bacille Calmette Guerin (BCG). This knowledge should be …

Like vaccines, biologic proteins can be very immunogenic for reasons including route of
administration, dose frequency and the underlying antigenicity of the therapeutic protein …

Objectives High accuracy diagnostic screening tests for tuberculosis (TB) are required to
improve the diagnosis of both active TB and latent Mycobacterium tuberculosis (MTB) …

In March 2009 a novel swine-origin influenza A (H1N1) virus (S-OIV) emerged in Mexico
and the Western United States. Vaccination with conventional influenza vaccine (CIV) does …