2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and
Management of Patients With Thoracic Aortic Disease | Circulation Science Volunteer Warning …

Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of aortic
aneurysm because the histology of thoracic aortic aneurysm (TAA) and abdominal aortic …

Objective—Recent studies suggested the occurrence of phenotypic switching of vascular
smooth muscle cells (VSMCs) during the development of aortic aneurysm (AA). However …

TGF-β is essential for vascular development; however, excess TGF-β signaling promotes
thoracic aortic aneurysm and dissection in multiple disorders, including Marfan syndrome …

Rationale: Aging represents a major risk factor for coronary artery disease and aortic
aneurysm formation. MicroRNAs (miRs) have emerged as key regulators of biological …

BAV aortas have histopathological findings similar to those of Marfan syndrome aortas, the
underlying genetic abnormality of Marfan syndrome—mutation in the FBN1 gene that …

Thoracic aortic aneurysms leading to type A dissections (TAAD) can be inherited in isolation
or in association with genetic syndromes, such as Marfan syndrome and Loeys-Dietz …

Background—Acute aortic dissection (AAD) is a life-threatening vascular disease without
effective pharmaceutical therapy. Matrix metalloproteinases (MMPs) are implicated in the …

Thoracic aortic aneurysm (TAA) is a localized or diffuse dilatation of the thoracic aortas, and
causes many sudden deaths each year worldwide. However, there is no effective …

Proteoglycan accumulation is a hallmark of medial degeneration in thoracic aortic aneurysm
and dissection (TAAD). Here, we defined the aortic proteoglycanome using mass …