The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2
(SARS-CoV-2) poses an unprecedented challenge to humanity. SARS-CoV-2 infections …

Coronavirus disease (COVID-19) presents a broad spectrum of clinical manifestations
ranging from an asymptomatic to a severe clinical course. The host genetic background …

The COVID-19 pandemic has markedly impacted on cultural, political, and economic
structures all over the world. Several aspects of its pathogenesis and related clinical …

Highlights•Variation in both HLA and SARS-CoV-2 impact antigen presentation to T
cells.•HLA variation influences COVID-19 outcomes and T-cell responses to SARS-CoV …

The COVID-19 pandemic has spawned global health crisis of unprecedented magnitude,
claiming millions of lives and pushing healthcare systems in many countries to the brink …

Quantifying variable importance is essential for answering high-stakes questions in fields
like genetics, public policy, and medicine. Current methods generally calculate variable …

Although advanced age and presence of comorbidities significantly impact the variation
observed in the clinical symptoms of COVID-19, it has been suggested that genetic variants …

Background COVID-19 is associated with several risk factors such as distinct ethnicities
(genetic ancestry), races, sexes, age, pre-existing comorbidities, smoking, and genetics. The …

Evolutionary pressures sculpt population genetics, whereas immune adaptation fortifies
humans against life-threatening organisms. How the evolution of selective genetic variation …

Although advanced age, male sex, and some comorbidities impact the clinical course of
COVID-19, these factors only partially explain the inter-individual variability in disease …