Lipids must be correctly transported within the cell to the right place at the right time in order
to be fully functional. Non-vesicular lipid transport is mediated by so-called lipid transfer …

VAP-A is a major endoplasmic reticulum (ER) receptor that allows this organelle to engage
numerous membrane contact sites with other organelles. One highly studied example is the …

Lysosomes serve dual antagonistic functions in cells by mediating anabolic growth signaling
and the catabolic turnover of macromolecules. How these janus-faced activities are …

Abnormal distribution of cellular cholesterol is associated with numerous diseases, including
cardiovascular and neurodegenerative diseases. Regulated transport of cholesterol is …

Cholesterol is important for membrane integrity and cell signaling, and dysregulation of the
distribution of cellular cholesterol is associated with numerous diseases, including …

Oxysterol binding protein (OSBP) extracts cholesterol from the ER to deliver it to the TGN via
counter exchange and subsequent hydrolysis of the phosphoinositide PI (4) P. Here, we …

Sterol-binding proteins are important regulators of lipid homeostasis and membrane
integrity; however, the discovery of selective modulators can be challenging due to structural …

Membrane contact sites (MCSs) are heterogeneous in shape, composition, and dynamics.
Despite this diversity, VAP proteins act as receptors for multiple FFAT motif-containing …

Schweinfurthins (SWs) are naturally occurring prenylated stilbenes with promising
anticancer properties. They act through a novel mechanism of action similar to that of other …

Oxysterol-binding protein (OSBP), which transports cholesterol and phosphatidylinositol 4-
monophosphate (PtdIns [4] P) between different organelles, serves as a conserved host …