Background The pathogenesis and treatment of ulcerative colitis remain poorly understood.
The aim of the present study is to investigate the effects of black cumin (Nigella sativa) oil on …

To explore the physiological functions of endothelin-2 (ET-2), we generated gene-targeted
mouse models. Global Et2 knockout mice exhibited severe growth retardation and juvenile …

Endothelin, a potent endogenous vasoconstrictor and mitogen that acts through the ETA and
ETB receptors, has been not only implicated in the regulation of cardiovascular homeostasis …

(1) To verify the proposed role of reactive oxygen species (ROS) in ulcerative colitis, the
effect of an antioxidant N-acetylcysteine (NAC) was studied in acetic acid (AA)-induced …

Endothelin (ET) receptor antagonists have been developed to produce a reduction of ET
related effects in various diseases, as well as in animal models of airway inflammation. We …

After intracolonic administration of trinitrobenzene sulphonic acid (TNBS), Sprague-Dawley
rats were treated orally either with saline or erdosteine (100 mg/kg per day), a sulfhydryl …

This study aimed to evaluate the effectiveness of bosentan as a protective agent on the rat's
cheek mucosa for Methotrexate-induced oral mucositis. Twenty-four Wister-albino rats …

Background and aims Endothelins, a group of polyfunctional cytokines, induce the adhesion
of circulating leucocytes to venous endothelium, an initial step in the pathogenesis of a …

Objectives: The aim of the present study was to investigate the time dependent changes in
hemodynamic parameters and to assess the role of endothelin (ET) receptors in …

Inflammatory bowel diseases (IBDs) such as ulcerative colitis and Crohn's disease affect the
mucosa of the luminal organs of the alimentary tract, mostly small and large bowel. They are …