N-Methyl-D-aspartate ionotropic glutamate receptors (NMDARs) play key roles in
synaptogenesis, synaptic maturation, long-term plasticity, neuronal network activity, and …

Chronic pain is a frequent, distressing and poorly understood health problem. Plasticity of
synaptic transmission in the nociceptive pathways after inflammation or injury is assumed to …

Here, we describe an approach to correct the genetic defect in fragile X syndrome (FXS) via
recruitment of endogenous repair mechanisms. A leading cause of autism spectrum …

Neurotransmission in the brain is unreliable, suggesting that high-frequency spike bursts
rather than individual spikes carry the neural code. For instance, cortical pyramidal neurons …

MECP2, CDKL5, and FMR1 are three X-linked neurodevelopmental genes associated with
Rett, CDKL5-, and fragile-X syndrome, respectively. These syndromes are characterized by …

Schizophrenia is a polygenetic disease, the heterogeneity of which is likely complicated by
epigenetic modifications yet to be elucidated. Here, we performed transcriptomic analysis of …

Glutamate is the major excitatory neurotransmitter in the central nervous system.
Glutamatergic transmission can be mediated by ionotropic glutamate receptors (iGluRs) …

NMDA receptors play vital roles in a broad array of essential brain functions, from synaptic
transmission and plasticity to learning and memory. Historically, the fundamental roles of …

Experience-dependent refinement of neuronal connections is critically important for brain
development and learning. Here, we show that ion-flow-independent NMDA receptor …

Fragile X syndrome (FXS) is caused by silencing of the human FMR1 gene and is the
leading monogenic cause of intellectual disability and autism. Abundant preclinical data …