Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …

The diagnosis of neurodegenerative disorders is often challenging due to the lack of
diagnostic tools, comorbidities and shared pathological manifestations. Synaptic dysfunction …

Synaptic dysfunction and degeneration is likely the key pathophysiology for the progression
of cognitive decline in various dementia disorders. Synaptic status can be monitored by …

Memory loss in Alzheimer's disease (AD) is attributed to pervasive weakening and loss of
synapses. Here, we present findings supporting a special role for excitatory synapses …

Abstract Chitinase‐3‐like protein 1 (CHI3L1/YKL‐40) has long been known as a biomarker
for early detection of neuroinflammation and disease diagnosis of Alzheimer's disease (AD) …

Background Synaptic dysfunction and degeneration are central contributors to the
pathogenesis and progression of parkinsonian disorders. Therefore, identification and …

Introduction Synaptic dysfunction and degeneration is one of the earliest events in
Alzheimer's disease (AD) and the best correlate of cognitive decline. Thus, identification and …

Purpose The aim of this study is to identify the potential cerebrospinal fluid (CSF) biomarkers
for Alzheimer's disease and to evaluate these markers on independent CSF samples using …

Abstract Introduction Amyloid, Tau, and neurodegeneration biomarkers can stage
Alzheimer's Disease (AD). Synaptic biomarkers may help track cognition. Methods In …

Introduction: Biomarkers that reflect pathologic processes affecting neuronal function during
preclinical and early stages of Alzheimer's disease (AD) are needed to aid drug …