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Targeting non-coding RNAs to overcome cancer therapy resistance
BQ Chen, MP Dragomir, C Yang, Q Li, D Horst… - Signal transduction and …, 2022 - nature.com
It is now well known that non-coding RNAs (ncRNAs), rather than protein-coding transcripts,
are the preponderant RNA transcripts. NcRNAs, particularly microRNAs (miRNAs), long non …
are the preponderant RNA transcripts. NcRNAs, particularly microRNAs (miRNAs), long non …
Long noncoding RNAs as biomarkers in cancer
Long noncoding RNAs (lncRNAs) are a relatively well‐characterized class of noncoding
RNA (ncRNA) molecules, involved in the regulation of various cell processes, including …
RNA (ncRNA) molecules, involved in the regulation of various cell processes, including …
A novel urine exosome gene expression assay to predict high-grade prostate cancer at initial biopsy
J McKiernan, MJ Donovan, V O'Neill, S Bentink… - JAMA …, 2016 - jamanetwork.com
Importance Overdiagnosis and overtreatment of indolent prostate cancer (PCA) is a serious
health issue in most developed countries. There is an unmet clinical need for noninvasive …
health issue in most developed countries. There is an unmet clinical need for noninvasive …
MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures
Long noncoding RNAs (lncRNAs) regulate gene expression by association with chromatin,
but how they target chromatin remains poorly understood. We have used chromatin RNA …
but how they target chromatin remains poorly understood. We have used chromatin RNA …
[HTML][HTML] A prospective adaptive utility trial to validate performance of a novel urine exosome gene expression assay to predict high-grade prostate cancer in patients …
Background Discriminating indolent from clinically significant prostate cancer (PCa) in the
initial biopsy setting remains an important issue. Prospectively evaluated diagnostic assays …
initial biopsy setting remains an important issue. Prospectively evaluated diagnostic assays …
Diagnosis of prostate cancer
JL Descotes - Asian journal of urology, 2019 - Elsevier
Diagnosis of prostate cancer (PCa) and adequate staging play a fundamental role for
clinical and patient care. Despite major advances in biology and imaging, rectal examination …
clinical and patient care. Despite major advances in biology and imaging, rectal examination …
Long noncoding RNA and cancer: a new paradigm
In addition to mutations or aberrant expression in the protein-coding genes, mutations and
misregulation of noncoding RNAs, in particular long noncoding RNAs (lncRNA), appear to …
misregulation of noncoding RNAs, in particular long noncoding RNAs (lncRNA), appear to …
Prostate cancer screening using a combination of risk-prediction, MRI, and targeted prostate biopsies (STHLM3-MRI): a prospective, population-based, randomised …
Background Screening for prostate cancer using prostate-specific antigen (PSA) reduces
prostate cancer mortality but can lead to adverse outcomes. We aimed to compare a …
prostate cancer mortality but can lead to adverse outcomes. We aimed to compare a …
Emerging biomarkers in the diagnosis of prostate cancer
X Filella, E Fernandez-Galan… - Pharmacogenomics …, 2018 - Taylor & Francis
Prostate cancer (PCa) is the second most common cancer in men worldwide. A large
proportion of PCa are latent, never destined to progress or affect the patients' life. It is of …
proportion of PCa are latent, never destined to progress or affect the patients' life. It is of …
Prediction medicine: biomarkers, risk calculators and magnetic resonance imaging as risk stratification tools in prostate cancer diagnosis
This review discusses the most recent evidence for currently available risk stratification tools
in the detection of clinically significant prostate cancer (csPCa), and evaluates diagnostic …
in the detection of clinically significant prostate cancer (csPCa), and evaluates diagnostic …