Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials
M Dambrova, M Makrecka-Kuka, J Kuka… - Pharmacological …, 2022 - Elsevier
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …
metabolism pathways. They have historically been used as important diagnostic markers for …
Type 2 diabetes in youth: the role of early life exposures
A Rughani, JE Friedman, JB Tryggestad - Current diabetes reports, 2020 - Springer
Abstract Purpose of Review This review examines the impact of early life exposures on
glucose metabolism in the offspring and explores potential metabolic mechanisms leading …
glucose metabolism in the offspring and explores potential metabolic mechanisms leading …
Leveraging metabolic modeling to identify functional metabolic alterations associated with COVID-19 disease severity
Objective Since the COVID-19 pandemic began in early 2020, SARS-CoV2 has claimed
more than six million lives world-wide, with over 510 million cases to date. To reduce …
more than six million lives world-wide, with over 510 million cases to date. To reduce …
A High-Throughput Integrated Nontargeted Metabolomics and Lipidomics Workflow Using Microelution Enhanced Matrix Removal-Lipid for Comparative Analysis of …
W Wu, K Wang, J Liu, PK So, TF Leung… - Analytical …, 2025 - ACS Publications
Sample pretreatment for mass spectrometry (MS)-based metabolomics and lipidomics is
normally conducted independently with two sample aliquots and separate matrix cleanup …
normally conducted independently with two sample aliquots and separate matrix cleanup …
Maternal Acylcarnitine Disruption as a Potential Predictor of Preterm Birth in Primigravida: A Preliminary Investigation
Preterm birth, defined as any birth before 37 weeks of completed gestation, poses adverse
health risks to both mothers and infants. Despite preterm birth being associated with several …
health risks to both mothers and infants. Despite preterm birth being associated with several …
The influence of maternal prepregnancy weight and gestational weight gain on the umbilical cord blood metabolome: a case–control study
X Yuan, Y Ma, J Wang, Y Zhao, W Zheng… - BMC Pregnancy and …, 2024 - Springer
Background Maternal overweight/obesity and excessive gestational weight gain (GWG) are
frequently reported to be risk factors for obesity and other metabolic disorders in offspring …
frequently reported to be risk factors for obesity and other metabolic disorders in offspring …
Metabolomic signatures of low-and high-adiposity neonates differ based on maternal BMI
BA Mathyk, BD Piccolo, F Alvarado… - American Journal …, 2022 - journals.physiology.org
Maternal obesity [body mass index (BMI)> 30 kg/m 2] is associated with greater neonatal
adiposity, cord blood (CB) insulin levels, and a proinflammatory phenotype at birth …
adiposity, cord blood (CB) insulin levels, and a proinflammatory phenotype at birth …
The clinical impact of maternal weight on offspring health: lights and shadows in breast milk metabolome
Introduction Pre-pregnancy overweight and obesity, depending on maternal nutrition and
metabolic state, can influence fetal, neonatal, and long-term offspring health, regarding …
metabolic state, can influence fetal, neonatal, and long-term offspring health, regarding …
Association of Maternal Diet during Pregnancy and Metabolite Profile in Cord Blood
CP Harris, C Ramlochansingh, O Uhl, H Demmelmair… - Biomolecules, 2022 - mdpi.com
Cord blood metabolites can be predictive of long-term disease risk, but how levels of
different metabolites might vary with respect to maternal diet is not well understood. The aim …
different metabolites might vary with respect to maternal diet is not well understood. The aim …
Multi-omics Analysis of Umbilical Cord Hematopoietic Stem Cells from a Multi-ethnic Cohort of Hawaii Reveals the Transgenerational Effect of Maternal Pre …
Y Du, PA Benny, Y Shao, RJ Schlueter, A Gurary… - medRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Background: Maternal obesity is a health concern that may predispose newborns to a high
risk of medical problems later in life. To understand the transgenerational effect of maternal …
risk of medical problems later in life. To understand the transgenerational effect of maternal …