Interest in neurofilaments has risen sharply in recent years with recognition of their potential
as biomarkers of brain injury or neurodegeneration in CSF and blood. This is in the context …

Autophagy is a lysosomal degradation process and protective housekee** mechanism to
eliminate damaged organelles, long-lived misfolded proteins and invading pathogens …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Macroautophagy/autophagy is vital for neuronal homeostasis and functions. Accumulating
evidence suggest that autophagy is impaired during cerebral ischemia, contributing to …

Selective autophagy of mitochondria, known as mitophagy, is an important mitochondrial
quality control mechanism that eliminates damaged mitochondria. Mitophagy also mediates …

Mechanisms of protein homeostasis are crucial for overseeing the clearance of misfolded
and toxic proteins over the lifetime of an organism, thereby ensuring the health of neurons …

Fragile X messenger ribonucleoprotein 1 protein (FMRP) binds many mRNA targets in the
brain. The contribution of these targets to fragile X syndrome (FXS) and related autism …

Stroke is the second leading cause of death, after ischemic heart disease, and accounts for
9% of deaths worldwide. According to the World Health Organization [WHO], 15 million …

Autophagy has been implicated in many physiological and pathological processes.
Accordingly, there is a growing scientific need to accurately identify, quantify, and …

Cerebral ischemia-reperfusion (IR) is a complex pathological process. Although autophagy
can be evoked by ischemia, its involvement in the reperfusion phase after ischemia and its …