Computational models for clinical applications in personalized medicine—guidelines and recommendations for data integration and model validation
The future development of personalized medicine depends on a vast exchange of data from
different sources, as well as harmonized integrative analysis of large-scale clinical health …
different sources, as well as harmonized integrative analysis of large-scale clinical health …
Renin–angiotensin–aldosterone pathway modulators in chronic kidney disease: A comparative review
S Alshahrani - Frontiers in Pharmacology, 2023 - frontiersin.org
Chronic kidney disease presents a health challenge that has a complex underlying
pathophysiology, both acquired and inherited. The pharmacotherapeutic treatment options …
pathophysiology, both acquired and inherited. The pharmacotherapeutic treatment options …
Physiologically based pharmacokinetic model to predict metoprolol disposition in healthy and disease populations
The evolution in the development of drugs has increased the popularity of physiologically
based pharmacokinetic (PBPK) models. This study seeks to assess the PK of metoprolol in …
based pharmacokinetic (PBPK) models. This study seeks to assess the PK of metoprolol in …
In-depth analysis of physiologically based pharmacokinetic (PBPK) modeling utilization in different application fields using text mining tools
In the past decade, only a small number of papers have elaborated on the application of
physiologically based pharmacokinetic (PBPK) modeling across different areas. In this …
physiologically based pharmacokinetic (PBPK) modeling across different areas. In this …
Application of physiologically based pharmacokinetic modeling to evaluate the drug–drug and drug–disease interactions of apatinib
H Liu, Y Yu, N Guo, X Wang, B Han… - Frontiers in …, 2021 - frontiersin.org
Aim: Apatinib is an orally administered vascular epidermal growth factor receptor (VEGFR)-
tyrosine kinase inhibitors approved for the treatment of advanced gastric adenocarcinoma or …
tyrosine kinase inhibitors approved for the treatment of advanced gastric adenocarcinoma or …
[HTML][HTML] A physiologically based pharmacokinetic model of cefepime to predict its pharmacokinetics in healthy, pediatric and disease populations
The physiologically based pharmacokinetic modeling (PBPK) approach can predict drug
pharmacokinetics (PK) by combining changes in blood flow and pathophysiological …
pharmacokinetics (PK) by combining changes in blood flow and pathophysiological …
Key factors in effective patient-tailored dosing of fluoroquinolones in urological infections: Interindividual pharmacokinetic and pharmacodynamic variability
O Estradé, V Vozmediano, N Carral, A Isla, M González… - Antibiotics, 2022 - mdpi.com
Fluoroquinolones (FQs) are a critical group of antimicrobials prescribed in urological
infections as they have a broad antimicrobial spectrum of activity and a favorable tissue …
infections as they have a broad antimicrobial spectrum of activity and a favorable tissue …
Assessment of aging-related function variations of P-gp transporter in old-elderly Chinese CHF patients based on modeling and simulation
C Cui, Y Qu, JEV Sia, Z Zhu, Y Wang, J Ling, H Li… - Clinical …, 2022 - Springer
Background and Objectives P-glycoprotein (P-gp) is one of the most intensely studied
transporters owing to its broad tissue distribution and substrate specificity. Existing research …
transporters owing to its broad tissue distribution and substrate specificity. Existing research …
Predicting transporter mediated drug–drug interactions via static and dynamic physiologically based pharmacokinetic modeling: A comprehensive insight on where …
The greater utilization and acceptance of physiologically‐based pharmacokinetic (PBPK)
modeling to evaluate the potential metabolic drug–drug interactions is evident by the …
modeling to evaluate the potential metabolic drug–drug interactions is evident by the …
[HTML][HTML] Predicting Food–Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling
F Lin, Y Hu, Y Zhang, L Zhao, D Zhong… - International Journal of …, 2024 - mdpi.com
Piperine has been reported to inhibit the enzyme activity of cytochrome P450 (CYP) 3A4.
The aim of this study was to develop and validate a physiologically based pharmacokinetic …
The aim of this study was to develop and validate a physiologically based pharmacokinetic …