The biology of regeneration failure and success after spinal cord injury

AP Tran, PM Warren, J Silver - Physiological reviews, 2018 - journals.physiology.org
Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Heterogeneity of astrocytic form and function

NA Oberheim, SA Goldman, M Nedergaard - Astrocytes: Methods and …, 2012 - Springer
Astrocytes participate in all essential CNS functions, including blood flow regulation, energy
metabolism, ion and water homeostasis, immune defence, neurotransmission, and adult …

Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences

K Shaw, L Bell, K Boyd, DM Grijseels, D Clarke… - Nature …, 2021 - nature.com
The hippocampus is essential for spatial and episodic memory but is damaged early in
Alzheimer's disease and is very sensitive to hypoxia. Understanding how it regulates its …

Contractile pericytes determine the direction of blood flow at capillary junctions

AL Gonzales, NR Klug, A Moshkforoush, JC Lee… - Proceedings of the …, 2020 - pnas.org
The essential function of the circulatory system is to continuously and efficiently supply the
O2 and nutrients necessary to meet the metabolic demands of every cell in the body, a …

NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration

SH Kang, M Fukaya, JK Yang, JD Rothstein… - Neuron, 2010 - cell.com
The mammalian CNS contains a ubiquitous population of glial progenitors known as NG2+
cells that have the ability to develop into oligodendrocytes and undergo dramatic changes in …

Regional astrocyte allocation regulates CNS synaptogenesis and repair

HH Tsai, H Li, LC Fuentealba, AV Molofsky… - Science, 2012 - science.org
Astrocytes, the most abundant cell population in the central nervous system (CNS), are
essential for normal neurological function. We show that astrocytes are allocated to spatial …

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

T Philips, W Robberecht - The Lancet Neurology, 2011 - thelancet.com
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis (ALS) are characterised by the appearance of reactive …

[HTML][HTML] Origin of new glial cells in intact and injured adult spinal cord

F Barnabé-Heider, C Göritz, H Sabelström… - Cell stem cell, 2010 - cell.com
Several distinct cell types in the adult central nervous system have been suggested to act as
stem or progenitor cells generating new cells under physiological or pathological conditions …

Tissue specific origin, development, and pathological perspectives of pericytes

T Yamazaki, Y Mukouyama - Frontiers in cardiovascular medicine, 2018 - frontiersin.org
Pericytes are mural cells surrounding blood vessels, adjacent to endothelial cells. Pericytes
play critical roles in maturation and maintenance of vascular branching morphogenesis. In …

NG 2‐glia and their functions in the central nervous system

L Dimou, V Gallo - Glia, 2015 - Wiley Online Library
In the central nervous system, NG2‐glia represent a neural cell population that is distinct
from neurons, astrocytes, and oligodendrocytes. While in the past the main role ascribed to …