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The biology of regeneration failure and success after spinal cord injury
AP Tran, PM Warren, J Silver - Physiological reviews, 2018 - journals.physiology.org
Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …
Heterogeneity of astrocytic form and function
Astrocytes participate in all essential CNS functions, including blood flow regulation, energy
metabolism, ion and water homeostasis, immune defence, neurotransmission, and adult …
metabolism, ion and water homeostasis, immune defence, neurotransmission, and adult …
Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences
The hippocampus is essential for spatial and episodic memory but is damaged early in
Alzheimer's disease and is very sensitive to hypoxia. Understanding how it regulates its …
Alzheimer's disease and is very sensitive to hypoxia. Understanding how it regulates its …
Contractile pericytes determine the direction of blood flow at capillary junctions
The essential function of the circulatory system is to continuously and efficiently supply the
O2 and nutrients necessary to meet the metabolic demands of every cell in the body, a …
O2 and nutrients necessary to meet the metabolic demands of every cell in the body, a …
NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration
The mammalian CNS contains a ubiquitous population of glial progenitors known as NG2+
cells that have the ability to develop into oligodendrocytes and undergo dramatic changes in …
cells that have the ability to develop into oligodendrocytes and undergo dramatic changes in …
Regional astrocyte allocation regulates CNS synaptogenesis and repair
HH Tsai, H Li, LC Fuentealba, AV Molofsky… - Science, 2012 - science.org
Astrocytes, the most abundant cell population in the central nervous system (CNS), are
essential for normal neurological function. We show that astrocytes are allocated to spatial …
essential for normal neurological function. We show that astrocytes are allocated to spatial …
Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease
T Philips, W Robberecht - The Lancet Neurology, 2011 - thelancet.com
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis (ALS) are characterised by the appearance of reactive …
amyotrophic lateral sclerosis (ALS) are characterised by the appearance of reactive …
[HTML][HTML] Origin of new glial cells in intact and injured adult spinal cord
F Barnabé-Heider, C Göritz, H Sabelström… - Cell stem cell, 2010 - cell.com
Several distinct cell types in the adult central nervous system have been suggested to act as
stem or progenitor cells generating new cells under physiological or pathological conditions …
stem or progenitor cells generating new cells under physiological or pathological conditions …
Tissue specific origin, development, and pathological perspectives of pericytes
T Yamazaki, Y Mukouyama - Frontiers in cardiovascular medicine, 2018 - frontiersin.org
Pericytes are mural cells surrounding blood vessels, adjacent to endothelial cells. Pericytes
play critical roles in maturation and maintenance of vascular branching morphogenesis. In …
play critical roles in maturation and maintenance of vascular branching morphogenesis. In …
NG 2‐glia and their functions in the central nervous system
L Dimou, V Gallo - Glia, 2015 - Wiley Online Library
In the central nervous system, NG2‐glia represent a neural cell population that is distinct
from neurons, astrocytes, and oligodendrocytes. While in the past the main role ascribed to …
from neurons, astrocytes, and oligodendrocytes. While in the past the main role ascribed to …