The neural circuits underlying general anesthesia and sleep
General anesthesia is characterized by loss of consciousness, amnesia, analgesia, and
immobility. Important molecular targets of general anesthetics have been identified, but the …
immobility. Important molecular targets of general anesthetics have been identified, but the …
Anesthesia and the neurobiology of consciousness
In the 19 th century, the discovery of general anesthesia revolutionized medical care. In the
21 st century, anesthetics have become indispensable tools to study consciousness. Here, I …
21 st century, anesthetics have become indispensable tools to study consciousness. Here, I …
Multimodal MRI reveals brainstem connections that sustain wakefulness in human consciousness
Consciousness is composed of arousal (ie, wakefulness) and awareness. Substantial
progress has been made in map** the cortical networks that underlie awareness in the …
progress has been made in map** the cortical networks that underlie awareness in the …
Deep brain stimulation of the thalamus restores signatures of consciousness in a nonhuman primate model
Loss of consciousness is associated with the disruption of long-range thalamocortical and
corticocortical brain communication. We tested the hypothesis that deep brain stimulation …
corticocortical brain communication. We tested the hypothesis that deep brain stimulation …
[ספר][B] Miller's anesthesia, 2-volume set E-book
MA Gropper, LI Eriksson, LA Fleisher… - 2019 - books.google.com
Covering everything from historical and international perspectives to basic science and
current clinical practice, Miller's Anesthesia, 9th Edition, remains the preeminent reference in …
current clinical practice, Miller's Anesthesia, 9th Edition, remains the preeminent reference in …
GABA and glutamate neurons in the VTA regulate sleep and wakefulness
We screened for novel circuits in the mouse brain that promote wakefulness. Chemogenetic
activation experiments and electroencephalogram recordings pointed to …
activation experiments and electroencephalogram recordings pointed to …
Neuronal mechanisms for sleep/wake regulation and modulatory drive
Humans have been fascinated by sleep for millennia. After almost a century of scientific
interrogation, significant progress has been made in understanding the neuronal regulation …
interrogation, significant progress has been made in understanding the neuronal regulation …
Dorsal raphe dopamine neurons modulate arousal and promote wakefulness by salient stimuli
Ventral midbrain dopamine (DA) is unambiguously involved in motivation and behavioral
arousal, yet the contributions of other DA populations to these processes are poorly …
arousal, yet the contributions of other DA populations to these processes are poorly …
Towards a comprehensive understanding of anesthetic mechanisms of action: a decade of discovery
Significant progress has been made in the 21st century towards a comprehensive
understanding of the mechanisms of action of general anesthetics, coincident with progress …
understanding of the mechanisms of action of general anesthetics, coincident with progress …
Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation
The specific circuit mechanisms through which anesthetics induce unconsciousness have
not been completely characterized. We recorded neural activity from the frontal, parietal, and …
not been completely characterized. We recorded neural activity from the frontal, parietal, and …