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Unsupervised machine learning for exploratory data analysis in imaging mass spectrometry
Imaging mass spectrometry (IMS) is a rapidly advancing molecular imaging modality that
can map the spatial distribution of molecules with high chemical specificity. IMS does not …
can map the spatial distribution of molecules with high chemical specificity. IMS does not …
Mass spectrometry imaging with high resolution in mass and space
A Römpp, B Spengler - Histochemistry and cell biology, 2013 - Springer
Mass spectrometry (MS) imaging links molecular information and the spatial distribution of
analytes within a sample. In contrast to most histochemical techniques, mass spectrometry …
analytes within a sample. In contrast to most histochemical techniques, mass spectrometry …
Highly multiplexed immunohistochemical MALDI-MS imaging of biomarkers in tissues
Immunohistochemistry (IHC) combined with fluorescence microscopy provides an important
and widely used tool for researchers and pathologists to image multiple biomarkers in tissue …
and widely used tool for researchers and pathologists to image multiple biomarkers in tissue …
Gold Nanorods for Ovarian Cancer Detection with Photoacoustic Imaging and Resection Guidance via Raman Imaging in Living Mice
Improved imaging approaches are needed for ovarian cancer screening, diagnosis, staging,
and resection guidance. Here, we propose a combined photoacoustic (PA)/Raman …
and resection guidance. Here, we propose a combined photoacoustic (PA)/Raman …
Multimodal Mass Spectrometry Imaging of N-Glycans and Proteins from the Same Tissue Section
B Heijs, S Holst, IH Briaire-de Bruijn… - Analytical …, 2016 - ACS Publications
On-tissue digestion matrix-assisted laser desorption/ionization mass spectrometry imaging
(MALDI-MSI) can be used to record spatially correlated molecular information from formalin …
(MALDI-MSI) can be used to record spatially correlated molecular information from formalin …
MALDI‐imaging for classification of epithelial ovarian cancer histotypes from a tissue microarray using machine learning methods
Purpose Precise histological classification of epithelial ovarian cancer (EOC) has immanent
diagnostic and therapeutic consequences, but remains challenging in histological routine …
diagnostic and therapeutic consequences, but remains challenging in histological routine …
Design and performance of a novel interface for combined matrix-assisted laser desorption ionization at elevated pressure and electrospray ionization with orbitrap …
Matrix-Assisted Laser Desorption Ionization, MALDI, has been increasingly used in a variety
of biomedical applications, including tissue imaging of clinical tissue samples, and in drug …
of biomedical applications, including tissue imaging of clinical tissue samples, and in drug …
MALDI imaging mass spectrometry for direct tissue analysis: technological advancements and recent applications
B Balluff, C Schöne, H Höfler, A Walch - Histochemistry and cell biology, 2011 - Springer
Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a
method that allows the investigation of the molecular content of tissues within its …
method that allows the investigation of the molecular content of tissues within its …
MALDI Mass Spectrometry Imaging of Early‐ and Late‐Stage Serous Ovarian Cancer Tissue Reveals Stage‐Specific N‐Glycans
Epithelial ovarian cancer is one of the most fatal gynecological malignancies in adult
women. As studies on protein N‐glycosylation have extensively reported aberrant patterns …
women. As studies on protein N‐glycosylation have extensively reported aberrant patterns …
Recent advances in single-cell MALDI mass spectrometry imaging and potential clinical impact
KJ Boggio, E Obasuyi, K Sugino… - Expert review of …, 2011 - Taylor & Francis
Single-cell analysis is gaining popularity in the field of mass spectrometry as a method for
analyzing protein and peptide content in cells. The spatial resolution of MALDI mass …
analyzing protein and peptide content in cells. The spatial resolution of MALDI mass …