Unsupervised machine learning for exploratory data analysis in imaging mass spectrometry

N Verbeeck, RM Caprioli… - Mass spectrometry …, 2020 - Wiley Online Library
Imaging mass spectrometry (IMS) is a rapidly advancing molecular imaging modality that
can map the spatial distribution of molecules with high chemical specificity. IMS does not …

Mass spectrometry imaging with high resolution in mass and space

A Römpp, B Spengler - Histochemistry and cell biology, 2013 - Springer
Mass spectrometry (MS) imaging links molecular information and the spatial distribution of
analytes within a sample. In contrast to most histochemical techniques, mass spectrometry …

Highly multiplexed immunohistochemical MALDI-MS imaging of biomarkers in tissues

G Yagnik, Z Liu, KJ Rothschild… - Journal of the American …, 2021 - ACS Publications
Immunohistochemistry (IHC) combined with fluorescence microscopy provides an important
and widely used tool for researchers and pathologists to image multiple biomarkers in tissue …

Gold Nanorods for Ovarian Cancer Detection with Photoacoustic Imaging and Resection Guidance via Raman Imaging in Living Mice

JV Jokerst, AJ Cole, D Van de Sompel, SS Gambhir - ACS nano, 2012 - ACS Publications
Improved imaging approaches are needed for ovarian cancer screening, diagnosis, staging,
and resection guidance. Here, we propose a combined photoacoustic (PA)/Raman …

Multimodal Mass Spectrometry Imaging of N-Glycans and Proteins from the Same Tissue Section

B Heijs, S Holst, IH Briaire-de Bruijn… - Analytical …, 2016 - ACS Publications
On-tissue digestion matrix-assisted laser desorption/ionization mass spectrometry imaging
(MALDI-MSI) can be used to record spatially correlated molecular information from formalin …

MALDI‐imaging for classification of epithelial ovarian cancer histotypes from a tissue microarray using machine learning methods

O Klein, F Kanter, H Kulbe, P Jank… - PROTEOMICS …, 2019 - Wiley Online Library
Purpose Precise histological classification of epithelial ovarian cancer (EOC) has immanent
diagnostic and therapeutic consequences, but remains challenging in histological routine …

Design and performance of a novel interface for combined matrix-assisted laser desorption ionization at elevated pressure and electrospray ionization with orbitrap …

ME Belov, SR Ellis, M Dilillo, MRL Paine… - Analytical …, 2017 - ACS Publications
Matrix-Assisted Laser Desorption Ionization, MALDI, has been increasingly used in a variety
of biomedical applications, including tissue imaging of clinical tissue samples, and in drug …

MALDI imaging mass spectrometry for direct tissue analysis: technological advancements and recent applications

B Balluff, C Schöne, H Höfler, A Walch - Histochemistry and cell biology, 2011 - Springer
Matrix assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a
method that allows the investigation of the molecular content of tissues within its …

MALDI Mass Spectrometry Imaging of Early‐ and Late‐Stage Serous Ovarian Cancer Tissue Reveals Stage‐Specific N‐Glycans

MT Briggs, MR Condina, YY Ho, AV Everest‐Dass… - …, 2019 - Wiley Online Library
Epithelial ovarian cancer is one of the most fatal gynecological malignancies in adult
women. As studies on protein N‐glycosylation have extensively reported aberrant patterns …

Recent advances in single-cell MALDI mass spectrometry imaging and potential clinical impact

KJ Boggio, E Obasuyi, K Sugino… - Expert review of …, 2011 - Taylor & Francis
Single-cell analysis is gaining popularity in the field of mass spectrometry as a method for
analyzing protein and peptide content in cells. The spatial resolution of MALDI mass …