Gastric cancer treatment: recent progress and future perspectives

WL Guan, Y He, RH Xu - Journal of hematology & oncology, 2023 - Springer
Gastric cancer (GC) is one of the most common malignancies worldwide. Most patients are
diagnosed at advanced stages due to the subtle symptoms of earlier disease and the low …

Updates on global epidemiology, risk and prognostic factors of gastric cancer

WJ Yang, HP Zhao, Y Yu, JH Wang… - World journal of …, 2023 - pmc.ncbi.nlm.nih.gov
Gastric cancer (GC) is defined as the primary epithelial malignancy derived from the
stomach, and it is a complicated and heterogeneous disease with multiple risk factors …

Sintilimab plus chemotherapy for unresectable gastric or gastroesophageal junction cancer: the ORIENT-16 randomized clinical trial

J Xu, H Jiang, Y Pan, K Gu, S Cang, L Han, Y Shu, J Li… - Jama, 2023 - jamanetwork.com
Importance Gastric and gastroesophageal junction cancers are diagnosed in more than 1
million people worldwide annually, and few effective treatments are available. Sintilimab, a …

Korean practice guidelines for gastric cancer 2022: an evidence-based, multidisciplinary approach

TH Kim, IH Kim, SJ Kang, M Choi, BH Kim… - Journal of gastric …, 2023 - pmc.ncbi.nlm.nih.gov
Gastric cancer is one of the most common cancers in Korea and the world. Since 2004, this
is the 4th gastric cancer guideline published in Korea which is the revised version of …

Signaling pathways and therapeutic interventions in gastric cancer

ZN Lei, QX Teng, Q Tian, W Chen, Y **e… - Signal transduction and …, 2022 - nature.com
Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

Post‐translational modifications of histones: Mechanisms, biological functions, and therapeutic targets

R Liu, J Wu, H Guo, W Yao, S Li, Y Lu, Y Jia… - MedComm, 2023 - Wiley Online Library
Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial

SQ Yuan, RC Nie, Y **, CC Liang, YF Li, R Jian… - Nature Medicine, 2024 - nature.com
Perioperative chemotherapy is the standard treatment for locally advanced gastric or gastro-
esophageal junction cancer, and the addition of programmed cell death 1 (PD-1) inhibitor is …

Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression

C Deng, M Huo, H Chu, X Zhuang, G Deng, W Li… - Molecular Cancer, 2024 - Springer
Circular RNAs (circRNAs) play important roles in gastric cancer progression but the
regulatory role of circRNAs in controlling macrophage function remains elusive. Exosomes …

Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions

H Ji, C Hu, X Yang, Y Liu, G Ji, S Ge, X Wang… - … and Targeted Therapy, 2023 - nature.com
Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune
modulation, and secondary dissemination to distant sites through a series of mechanisms …

The Chinese Society of Clinical Oncology (CSCO): clinical guidelines for the diagnosis and treatment of gastric cancer, 2021

FH Wang, XT Zhang, YF Li, L Tang, XJ Qu… - Cancer …, 2021 - Wiley Online Library
There exist differences in the epidemiological characteristics, clinicopathological features,
tumor biological characteristics, treatment patterns, and drug selections between gastric …