Type II collagen (CII), a key component of cartilaginous tissues, offers an attractive option for
fabricating biomimetic scaffolds that provide mechanical support and biochemical signals to …

The fibrocartilaginous enthesis is a highly specialised tissue interface that ensures a smooth
mechanical transfer between tendon or ligament and bone through a fibrocartilage area …

Implant-associated infections and insufficient osseointegration are still great challenges in
clinical load-bearing applications. Exploiting the antibacterial effects and immunomodulatory …

With the current developmental advancements in nanotechnology, nanofibrous scaffolds are
being widely used. The healing of fibrocartilaginous enthesis is a slow and complex …

Rotator cuff injuries present a clinical challenge for repair due to current limitations in
functional regeneration of the native tendon-to-bone enthesis. A biomaterial that can …

The musculoskeletal system relies on critical tissue interfaces for its function; however, these
interfaces are often compromised by injuries and diseases. Restoration of these interfaces is …

The design of implants for tissue transitions remains a major scientific challenge. This is due
to gradients in characteristics that need to be restored. The rotator cuff in the shoulder, with …

Tendon/ligament–bone junctions (T/LBJs) are susceptible to damage during exercise,
resulting in anterior cruciate ligament rupture or rotator cuff tear; however, their intricate …

Pursuing personalized medicine has spurred the development of drug delivery systems
inspired by autologous materials, underscoring the transition from natural origins to …

Surgical reattachment of tendon to bone is a clinical challenge, with unacceptably high
retear rates in the early period after repair. A primary reason for these repeated tears is that …