Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system
indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of …

PD1 was originally discovered in 1992 as a molecule associated with activation-induced cell
death in T cells. Over the past 30 years, it was found that PD1 has a critical role in avoiding …

For many solid malignancies, lymph node (LN) involvement represents a harbinger of
distant metastatic disease and, therefore, an important prognostic factor. Beyond its utility as …

Immune checkpoint blockade has provided a paradigm shift in cancer therapy, but the
success of this approach is very variable; therefore, biomarkers predictive of clinical efficacy …

The discovery of FOXP3+ regulatory T (Treg) cells as a distinct cell lineage with a central
role in regulating immune responses provided a deeper understanding of self-tolerance …

The success of cancer immunotherapy relies on the knowledge of the tumor
microenvironment and the immune evasion mechanisms in which the tumor, stroma, and …

Regulatory T cells (Treg cells) are essential for immune tolerance, but also drive
immunosuppression in the tumour microenvironment. Therapeutic targeting of Treg cells in …

With the broad application of cancer immunotherapies such as immune checkpoint inhibitors
in multiple cancer types, the immunological landscape in the tumor microenvironment (TME) …

Regulatory T (Treg) cells, an immunosuppressive subset of CD4+ T cells characterized by
the expression of the master transcription factor forkhead box protein P3 (FOXP3), are a …

The intestinal immune system is highly adapted to maintaining tolerance to the commensal
microbiota and self-antigens while defending against invading pathogens,. Recognizing …