Outer membrane protein folding from an energy landscape perspective

B Schiffrin, DJ Brockwell, SE Radford - BMC biology, 2017 - Springer
The cell envelope is essential for the survival of Gram-negative bacteria. This specialised
membrane is densely packed with outer membrane proteins (OMPs), which perform a …

Architecture and autoinhibitory mechanism of the plasma membrane Na+/H+ antiporter SOS1 in Arabidopsis

Y Wang, C Pan, Q Chen, Q **e, Y Gao, L He… - Nature …, 2023 - nature.com
Abstract Salt-overly-sensitive 1 (SOS1) is a unique electroneutral Na+/H+ antiporter at the
plasma membrane of higher plants and plays a central role in resisting salt stress. SOS1 is …

De novo design of transmembrane β barrels

AA Vorobieva, P White, B Liang, JE Horne, AK Bera… - Science, 2021 - science.org
INTRODUCTION Despite their key biological roles, only a few proteins that fold into lipid
membranes have been designed de novo. A class of membrane proteins—transmembrane …

Sculpting conducting nanopore size and shape through de novo protein design

S Berhanu, S Majumder, T Müntener, J Whitehouse… - Science, 2024 - science.org
Transmembrane β-barrels have considerable potential for a broad range of sensing
applications. Current engineering approaches for nanopore sensors are limited to naturally …

[HTML][HTML] Ecology and biogenesis of functional amyloids in Pseudomonas

SL Rouse, SJ Matthews, MS Dueholm - Journal of molecular biology, 2018 - Elsevier
Functional amyloids can be found in the extracellular matrix produced by many bacteria
during biofilm growth. They mediate the initial attachment of bacteria to surfaces and provide …

Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients

AN Calabrese, B Schiffrin, M Watson… - Nature …, 2020 - nature.com
The periplasmic chaperone SurA plays a key role in outer membrane protein (OMP)
biogenesis. E. coli SurA comprises a core domain and two peptidylprolyl isomerase …

Outer membrane protein insertion by the β-barrel assembly machine

DP Ricci, TJ Silhavy - EcoSal Plus, 2019 - Am Soc Microbiol
Like all outer membrane (OM) constituents, integral OM β-barrel proteins in Gram-negative
bacteria are synthesized in the cytoplasm and trafficked to the OM, where they are locally …

Transmembrane β-barrel proteins of bacteria: from structure to function

S Hermansen, D Linke, JC Leo - Advances in Protein Chemistry and …, 2022 - Elsevier
The outer membrane of Gram-negative bacteria is a specialized organelle conferring
protection to the cell against various environmental stresses and resistance to many harmful …

Biomimetic membranes with transmembrane proteins: State-of-the-art in transmembrane protein applications

H Ryu, A Fuwad, S Yoon, H Jang, JC Lee… - International Journal of …, 2019 - mdpi.com
In biological cells, membrane proteins are the most crucial component for the maintenance
of cell physiology and processes, including ion transportation, cell signaling, cell adhesion …

The Role of Extracellular Loops in the Folding of Outer Membrane Protein X (OmpX) of Escherichia coli

S Hermansen, D Ryoo, M Orwick-Rydmark… - Frontiers in Molecular …, 2022 - frontiersin.org
The outer membrane of Gram-negative bacteria acts as an additional diffusion barrier for
solutes and nutrients. It is perforated by outer membrane proteins (OMPs) that function most …