Multicellular tumor spheroids (MCTs) have been employed in biomedical fields owing to
their advantage in designing a three-dimensional (3D) solid tumor model. For controlling …

Organoid and spheroid technology provide valuable insights into developmental biology
and oncology. Optical coherence tomography (OCT) is a label-free technique that has …

Introduction: The research on tumor microenvironment (TME) has recently been gaining
attention due to its important role in tumor growth, progression, and response to therapy …

Photodynamic therapy (PDT) is a treatment which uses light-activated compounds to
produce reactive oxygen species, leading to membrane damage and cell death …

Gathering precise information on mass density, size and weight of cells or cell aggregates, is
crucial for applications in many biomedical fields with a specific focus on cancer research …

Background In the last years, several efforts have been made to classify colorectal cancer
(CRC) into well-defined molecular subgroups, representing the intrinsic inter-patient …

Substrates composition and surface features of materials rule adhesion control of cells to
surfaces. As a result, most of the aspects of cell functions, such as spreading, migration …

Multicellular tumor spheroid (MCTSs) models have demonstrated increasing utility for in vitro
study of cancer progression and drug discovery. These relatively simple avascular …

We developed adaptive optical (AO) two-photon excitation microscopy by introducing a
spatial light modulator (SLM) in a commercially available microscopy system. For correcting …

We demonstrate label-free dynamic optical coherence tomography (D-OCT)-based
visualization and quantitative assessment of patterns of tumor spheroid response to three …