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Isoxazole compounds: Unveiling the synthetic strategy, in-silico SAR & toxicity studies and future perspective as PARP inhibitor in cancer therapy
Latest developments in cancer treatment have shed a light on the crucial role of PARP
inhibitors that enhance the treatment effectiveness by modifying abnormal repair pathways …
inhibitors that enhance the treatment effectiveness by modifying abnormal repair pathways …
Electrochemical synthesis of pyrazolines and pyrazoles via [3+ 2] dipolar cycloaddition
M Linden, S Hofmann, A Herman… - Angewandte Chemie …, 2023 - Wiley Online Library
Pyrazolines and pyrazoles are common and important motifs of pharmaceutical agents and
agrochemicals. Herein, the first electrochemical approach for their direct synthesis from …
agrochemicals. Herein, the first electrochemical approach for their direct synthesis from …
A sequential multistep process for the fully mechanochemical, one-pot synthesis of the antiepileptic drug rufinamide
J Gómez-Carpintero, C Cabrero… - … Chemistry Letters and …, 2022 - Taylor & Francis
Mechanochemistry is a powerful tool to develop environmentally benign syntheses of active
pharmaceutical ingredients. In this context, we report here the synthesis of the anti-epileptic …
pharmaceutical ingredients. In this context, we report here the synthesis of the anti-epileptic …
Iodobenzene-Catalyzed Synthesis of Fully Functionalized NH-Pyrazoles and Isoxazoles from α, β-Unsaturated Hydrazones and Oximes via 1, 2-Aryl Shift
An iodine (III)-catalyzed general method for the synthesis of fully functionalized NH-
pyrazoles and isoxazoles from α, β-unsaturated hydrazones and oximes, respectively, via …
pyrazoles and isoxazoles from α, β-unsaturated hydrazones and oximes, respectively, via …
Synthesis of (4-trifluoromethyl) isoxazoles through a tandem trifluoromethyloximation/cyclization/elimination reaction of α, β-unsaturated carbonyls
We disclose a metal-free, cascade regio-and stereoselective trifluormethyloximation,
cyclization, and elimination strategy with readily available α, β-unsaturated carbonyl …
cyclization, and elimination strategy with readily available α, β-unsaturated carbonyl …
Construction of Highly Functionalized C4-Oxyacylated and Aminated Pyrazolines
Pyrazolines and pyrazolones are prevalent cores in drugs and bioactive molecules.
Functionalizing them with heteroatoms on the ring improves or expands their clinical …
Functionalizing them with heteroatoms on the ring improves or expands their clinical …
Rapid synthesis of fully substituted arylideneisoxazol-5(4H)-one using zinc oxide nanoparticles
A straightforward, rapid, green, and efficient synthetic procedure has been introduced for
easy access to the synthetically highly substituted arylideneisoxazol-5-(4 H)-one products. A …
easy access to the synthetically highly substituted arylideneisoxazol-5-(4 H)-one products. A …
Access to Isoxazoles via Photo-oxygenation of Furan Tethered α-Azidoketones
Photocatalyst-free visible light-enabled direct oxygenation of furan-tethered α-azidoketones
was studied. The reaction yielded various products depending on the substituents, with …
was studied. The reaction yielded various products depending on the substituents, with …
One-Pot Telescopic Approach to Synthesize Disubstituted Benzimidazoles in Deep Eutectic Solvent
An ongoing challenge in the pharmaceutical sector is the need to find and implement novel
synthetic approaches because traditional methods sometimes violate the principles of green …
synthetic approaches because traditional methods sometimes violate the principles of green …
Palladium-catalyzed cyclizative cross coupling of ynone oximes with 2-haloaryl N-acrylamides for isoxazolyl indoline bis-heterocycles
Metal-catalyzed cyclizative cross-coupling reactions have attracted enormous attention due
to their unique cascade nature. We demonstrated, herein, a dual-cyclizative coupling of …
to their unique cascade nature. We demonstrated, herein, a dual-cyclizative coupling of …