[HTML][HTML] Oxidative stress in malaria: potential benefits of antioxidant therapy

ARQ Gomes, N Cunha, ELP Varela… - International Journal of …, 2022 - mdpi.com
Malaria is an infectious disease and a serious public health problem in the world, with 3.3
billion people in endemic areas in 100 countries and about 200 million new cases each …

Parasite sensing of host nutrients and environmental cues

V Zuzarte-Luís, MM Mota - Cell Host & Microbe, 2018 - cell.com
Parasites undergo complex life cycles that comprise a wide variety of cellular differentiation
events in different host compartments and transmission across multiple hosts. As parasites …

[HTML][HTML] Perspective: L-arginine and L-citrulline supplementation in pregnancy: a potential strategy to improve birth outcomes in low-resource settings

AM Weckman, CR McDonald, JAB Baxter… - Advances in …, 2019 - Elsevier
The available data support the hypothesis that L-arginine or L-citrulline supplementation
would be suitable for implementation in resource-constrained settings and will enhance …

Arginine deficiency is involved in thrombocytopenia and immunosuppression in severe fever with thrombocytopenia syndrome

XK Li, QB Lu, WW Chen, W Xu, R Liu… - Science translational …, 2018 - science.org
Severe fever with thrombocytopenia syndrome (SFTS) caused by a recently identified
bunyavirus, SFTSV, is an emerging infectious disease with extensive geographical …

Increased brain microvascular hemoglobin concentrations in children with cerebral malaria

RL Smith, AK Ikeda, CA Rowley… - Science Translational …, 2023 - science.org
Brain swelling is associated with death from cerebral malaria, but it is unclear whether brain
swelling is caused by cerebral edema or vascular congestion—two pathological conditions …

Distinct amino acid and lipid perturbations characterize acute versus chronic malaria

RJ Cordy, R Patrapuvich, LN Lili, M Cabrera-Mora… - JCI …, 2019 - pmc.ncbi.nlm.nih.gov
Chronic malaria is a major public health problem and significant challenge for disease
eradication efforts. Despite its importance, the biological factors underpinning chronic …

Malaria in pregnancy and adverse birth outcomes: new mechanisms and therapeutic opportunities

M Ngai, AM Weckman, C Erice, CR McDonald… - Trends in …, 2020 - cell.com
Malaria infection during pregnancy is associated with adverse birth outcomes but underlying
mechanisms are poorly understood. Here, we discuss the impact of malaria in pregnancy on …

Diagnosis of cerebral malaria: Tools to reduce Plasmodium falciparum associated mortality

P Muppidi, E Wright, SC Wassmer… - Frontiers in cellular and …, 2023 - frontiersin.org
Cerebral malaria (CM) is a major cause of mortality in Plasmodium falciparum (Pf) infection
and is associated with the sequestration of parasitised erythrocytes in the microvasculature …

Malaria in pregnancy alters l-arginine bioavailability and placental vascular development

CR McDonald, LS Cahill, JL Gamble… - Science translational …, 2018 - science.org
Reducing adverse birth outcomes due to malaria in pregnancy (MIP) is a global health
priority. However, there are few safe and effective interventions. l-Arginine is an essential …

Insights into malaria pathogenesis gained from host metabolomics

HN Colvin, R Joice Cordy - PLoS Pathogens, 2020 - journals.plos.org
Malaria is a devastating disease caused by the protozoan parasite Plasmodium. The most
common Plasmodium species that infect humans are Plasmodium falciparum and …