Cancer is a systemic manifestation of aberrant cell cycle activity and dysregulated cell
growth. Genetic mutations can determine tumor onset by either augmenting cell division …

Cilia and mitotic spindles are microtubule (MT)-based, macromolecular machines that
consecutively assemble and disassemble during interphase and M phase of the cell cycle …

Proper segregation of chromosomes during mitosis depends on" amphitelic attachments"—
load-bearing connections of sister kinetochores to the opposite spindle poles via bundles of …

Mitotic spindle assembly is crucial for chromosome segregation and relies on bundles of
microtubules that extend from the poles and overlap in the middle. However, how these …

Error correction is central to many biological systems and is critical for protein function and
cell health. During mitosis, error correction is required for the faithful inheritance of genetic …

The cytoskeleton–a collection of polymeric filaments, molecular motors, and crosslinkers–is
a foundational example of active matter, and in the cell assembles into organelles that guide …

Stabilization of microtubule plus end-directed kinesin CENP-E at the metaphase
kinetochores is important for chromosome alignment, but its mechanism remains unclear …

During mitosis, the interaction of kinetochores (KTs) with microtubules (MTs) drives
chromosome congression to the spindle equator and supports the segregation of sister …

Kinesin-5 motor proteins play essential roles during mitosis in most organisms. Their
tetrameric structure and plus-end-directed motility allow them to bind to and move along …

During cell division, the microtubule nucleating and organizing organelle, known as the
centrosome, is a critical component of the mitotic spindle. In cells with two centrosomes …