Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified
nuclear protein with histone demethylase activity. In particular, it plays a special role in the …

Exhausted CD8+ T cells are key targets of immune checkpoint blockade therapy and their
ineffective reinvigoration limits the durable benefit in some cancer patients. Here, we …

Studies of alterations in histone methylation in cancer have led to the identification of histone
methyltransferases and demethylases as novel targets for therapy. Lysine-specific …

It is well-established that Lysine-specific demethylase 1 (LSD1, also known as KDM1A)
roles as a lysine demethylase canonically acting on H3K4me1/2 and H3K9me1/2 for …

LSD1 (KDM1A; BHC110; AOF2) was the first protein reported to exhibit histone demethylase
activity and has since been shown to have multiple essential roles in mammalian biology …

LSD1 (lysine specific demethylase; also known as KDM1A), the first histone demethylase
discovered, regulates cell-fate determination and is overexpressed in multiple cancers …

Intellectual disability (ID) is a prevailing neurodevelopmental condition associated with
impaired cognitive and adaptive behaviors. Many chromatin-modifying enzymes and other …

Alzheimer's disease (AD) is the major cause of dementia in Western societies. It progresses
asymptomatically during decades before being belatedly diagnosed when therapeutic …

A new exciting area in cancer research is the study of cancer stem cells (CSCs) and the
translational implications for putative epigenetic therapies targeted against them …