DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple
forms, and if allowed to persist, can promote genome instability and directly lead to various …

Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict
cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic …

DNA molecules in mitochondria, just like those in the nucleus of eukaryotic cells, are
constantly damaged by noxious agents. Eukaryotic cells have developed efficient …

Publisher Summary The p53 protein is a tight, hydrophobic central globule containing the
DNA binding domain, flanked by accessible N-and C-terminal regions. This protein is …

Genome instability has long been implicated as the main causal factor in aging. Somatic
cells are continuously exposed to various sources of DNA damage, from reactive oxygen …

Transformation of a normal cell to a malignant one requires phenotypic changes often
associated with each of the initiation, promotion and progression phases of the carcinogenic …

A wide range of cytotoxic and mutagenic DNA bases are removed by different DNA
glycosylases, which initiate the base excision repair pathway. DNA glycosylases cleave the …

Apurinic/apyrimidinic (AP) sites are one of the most frequent spontaneous lesions in DNA.
They are potentially mutagenic and lethal lesions that can block DNA replication and …

The chemical methylating agents methylmethane sulfonate (MMS) and N-methyl-N '-nitro-N-
nitrosoguanidine (MNNG) have been used for decades as classical DNA damaging agents …

The role of inflammation in carcinogenesis has been extensively investigated and well
documented. Many biochemical processes that are altered during chronic inflammation …