The accumulation of protein aggregates is the hallmark of many neurodegenerative
diseases. The dysregulation of protein homeostasis (or proteostasis) caused by acute …

This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

Amyloid oligomers have emerged as the most toxic species of amyloid-β (Aβ). This
hypothesis might explain the lack of correlation between amyloid plaques and memory …

Neurodegenerative diseases are commonly associated with the accumulation of
intracellular or extracellular protein aggregates. Recent studies suggest that these …

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are usually associated with
loss of dopaminergic neurons. Loss of substantia nigra neurons and presence of Lewy body …

Background Aggregation of alpha-synuclein (αsyn) and resulting cytotoxicity is a hallmark of
sporadic and familial Parkinson's disease (PD) as well as dementia with Lewy bodies, with …

Protein aggregation is the hallmark of several neurodegenerative disorders. These protein
aggregation (fibrillization) disorders are also known as amyloid disorders. The mechanism …

Aggregation of α-synuclein (α-syn) has been linked to the pathogenesis of Parkinson's
disease (PD) and other neurodegenerative diseases. Increasing evidence suggests that …

Increasing evidence suggests that amyloid peptides associated with a variety of
degenerative diseases induce neurotoxicity in their intermediate oligomeric state, rather …

The aberrant assembly of peptides and proteins into fibrillar aggregates proceeds through
oligomeric intermediates that are thought to be the primary pathogenic species in many …